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MAPK蛋白在乳腺癌中的表达及其意义

Keywords: MAPK,乳腺肿瘤,复发,转移,预后

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Abstract:

目的研究丝裂原活化蛋白激酶(MAPK)在乳腺癌中的表达及其与乳腺癌患者临床病理特征、复发转移及预后间的关系。方法采用免疫组织化学SP法检测80例乳腺癌组织和20例癌旁正常组织中的MAPK的表达水平。结果乳腺癌组织中MAPK阳性表达为45.0%(36/80),主要表达于细胞浆及部分细胞核,明显高于癌旁正常组织的15%(3/20)(P0.05)。MAPK阴性表达组5年生存率(84.1%)高于阳性表达组(41.7%)(P<0.05)。结论MAPK可能参与了乳腺癌的发生发展、侵袭转移,有可能成为乳腺癌预后不良的生物学指标之一。

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