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肌钙蛋白T、中介素等因子在大鼠房颤模型中的变化及意义

, PP. 657-660

Keywords: 房颤,心肌肌钙蛋白T,中介素,高敏C反应蛋白,同型半胱氨酸,大鼠

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Abstract:

目的探讨心肌肌钙蛋白T(cardiactropoinT,cTnT)、中介素(intermedin,IMD)、高敏C反应蛋白(high-sensitivityC-reactiveprotein,hs-CRP)和同型半胱氨酸(homocysteine,HCY)在大鼠房颤模型中的变化及意义。方法选用80只雄性SD大鼠,随机分为房颤1日组、房颤4日组、房颤7日组和对照组,每组20只。房颤组通过尾静脉注射乙酰胆碱-氯化钙混合液,每日1次,分别连续注射1、4、7d,建立3组房颤实验模型。对照组不做任何处理。各房颤组大鼠均于造模成功当天心脏取血,对照组与房颤1日组同日心脏取血,采用ELISA测定血清cTnT、IMD、hs-CRP和Hcy的水平。结果房颤1、4、7日组hs-CRP、cTnT水平均高于对照组(P<0.01),且其水平随着房颤时间的延长逐渐升高(P<0.01)。房颤4、7日组HCY水平高于对照组(P<0.01),且随着房颤时间的延长而升高(P<0.01)。房颤4、7日组IMD水平高于对照组,且房颤7日组IMD水平高于房颤1、4日组(P<0.01)。结论cTnT、IMD、hs-CRP和Hcy共同参与了房颤的发生和维持,通过干预上述因素可能会对临床房颤的预防和诊治有作用。

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