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8q24区域4个单核苷酸多态性与前列腺癌的相关研究

, PP. 608-614

Keywords: 染色体8q24区,前列腺癌,单核苷酸多态性

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Abstract:

目的探讨染色体8q24区4个单核苷酸多态性(SNP)rs6983267、rs1447295、rs10090154和rs7837688与北京居民中前列腺癌(PCa)的关联及其基因型和表型的关系。方法收集138名正常对照者和124例PCa患者的血液样本和其遗传、嗜好、临床、膳食习惯等信息。基于高分辨率熔解曲线分析技术(HRM),对124名PCa患者和138名正常对照者的4个SNP(rs6983267、rs1447295、rs10090154和rs7837688)位点进行基因分型。结果PCa与对照组间rs6983267(55.8%vs56.8%)、rs1447295(21.5%vs17.5%)、rs10090154(20.3%vs16.4%)、rs7837688(19.7%vs19.3%)各基因型分布差异无统计学意义(P>0.05)。数量性状分析发现,PCa患者中rs7837688的GG基因型携带者饮酒的酒精度数更高(P=0.022)。结论8q24区rs6983267、rs1447295、rs10090154和rs7837688多态性与北京居民中PCa的易感性可能无相关关系。

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