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加巴喷丁联合羟考酮对胰腺癌引发内脏痛的治疗作用

, PP. 331-334

Keywords: 加巴喷丁,羟考酮,胰腺癌,内脏痛

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Abstract:

目的分析加巴喷丁联合羟考酮对胰腺癌引发内脏痛的治疗效果,为临床治疗提供参考。方法选取83例因胰腺癌引起内脏痛患者作为研究对象,随机分为两组,A组40例,给予羟考酮缓释片治疗,B组43例,给予加巴喷丁联合羟考酮缓释片治疗。对所有患者于治疗前及治疗后不同时间点进行简明疼痛评估量表(BPI)测试,记录分析治疗过程中发生的不良反应、疼痛、生活质量及药物用量。结果A组患者入组后1、2、3、4周羟考酮用药量分别为(61.0±12.5)、(62.8±9.5)、(65.0±11.5)、(64.4±12.2)mg?d-1,均高于B组分别为(48.0±9.8)、(36.5±10.5)、(24.2±9.6)、(24.4±10.2)mg?d-1(P0.05);B组第4周缓解率为95.35%,A组为82.50%,差异有统计学意义(P<0.05);第4周,B组恶心、呕吐和便秘的发生率分别为6.98%、9.30%和18.60%,A组分别为15.0%、15.0%和37.50%,差异有统计学意义(P<0.05)。结论加巴喷丁联合羟考酮缓释片对于胰腺癌引发内脏痛疗效较好,可显著减少羟考酮的用量及不良反应发生率。

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