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火把花根预处理对油酸致大鼠急性肺损伤的作用研究

, PP. 248-251

Keywords: 急性肺损伤,火把花根,油酸

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Abstract:

目的探讨火把花根对油酸所致急性肺损伤大鼠的保护作用。方法SD大鼠45只随机分成正常对照组(N组)、急性肺损伤组(ALI组)和火把花组(C组),每组各15只。正常对照组每次2mL生理盐水,每天2次,连续灌胃10d,第10天灌胃后1h尾静脉注射生理盐水0.04mL?kg-1;ALI组生理盐水灌胃同正常对照组,第10天灌胃后1h尾静脉注射油酸(0.04mL?kg-1),复制大鼠ALI模型;火把花根组火把花根片灌胃10d600mg?(kg?d)-1,分每天2次进行,第10天灌胃后1h尾静脉注射油酸(0.04mL?kg-1)。各组注射油酸后4h采集肺组织,测定肺湿/干重比(W/D);采集静脉血、支气管肺泡灌洗液,测定肺通透指数(LPI);肺组织切片HE染色行肺损伤评分(LIS)。结果肉眼观察正常对照组肺组织未见明显异常;ALI组肿胀明显;火把花根组轻度肿胀。光镜下正常对照组未见明显病理改变;ALI组肺泡壁欠完整,肺泡腔内见大量炎症细胞浸润,红细胞渗出,肺泡间质明显水肿;火把花根组改变较ALI组明显减轻。ALI组LIS较正常对照组明显升高(P<0.01),火把花根组LIS明显低于ALI组(P<0.01),但仍高于正常对照组(P<0.05)。ALI组W/D和LPI分别较正常对照组、火把花根组升高(P<0.05),火把花根组W/D高于正常对照组(P<0.01),但火把花根组LPI与正常对照组无明显差异。结论火把花根对油酸所致大鼠急性肺损伤有一定的保护作用。

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