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绝经后ER阳性乳腺癌患者CYP2D6基因多态性与TAM治疗生存率的临床分析

, PP. 315-318

Keywords: 乳腺癌,绝经后,基因多态性,他莫昔芬

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Abstract:

目的探讨术后口服他莫昔芬(tamoxifen,TAM)内分泌治疗的绝经后ER阳性乳腺癌患者CYP2D6基因多态性与TAM治疗后生存情况的相关性。方法对2010年1月-2011年7月87例术后接受TAM治疗的绝经后ER阳性乳腺癌患者采用PCR方法检测CYP2D6的基因型,并对术后TAM治疗情况进行随访调查,平均随访时间约35个月,分析患者无复发生存和无瘤生存情况。结果CYP2D6基因型为*10/*10的患者无复发生存期(relapse-freetime,RFT)和无病生存期(disease-freesurvival,DFS)明显短于基因型为*1/*10和*1/*1的患者(P0.05);经归因分层分析,除肿瘤分期和腋窝淋巴结转移外,临床其他因素并不能成为患者生存情况的影响因素(P>0.05)。结论CYP2D6*1/*10基因多态性与绝经后ER阳性乳腺癌患者的术后TAM内分泌治疗的生存情况具有相关性,可能作为绝经后乳腺癌患者TAM疗效和预后估计的临床预测指标。

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