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不同剂量羟乙基淀粉对结直肠癌手术患者血液流变学的影响

, PP. 295-298

Keywords: 羟乙基淀粉130/0.4,血液流变学,结直肠癌手术

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Abstract:

目的研究不同剂量羟乙基淀粉(130/0.4)用于结直肠癌手术患者对血液流变学的影响。方法结直肠癌手术患者60例,按照羟乙基淀粉补充剂量不同随机分为3组(每组20例)A组10mL?kg-1、B组15mL?kg-1、C组20mL?kg-1。观察并记录扩容前(T0)、扩容结束后30min(T1)、扩容后3.5h(T2)后的高(200s-1)、中(30s-1)、低(5s-1)切变率下全血粘度、血浆粘度(ηp)、红细胞刚性指数(ERI)、红细胞聚集指数(EAI)、红细胞压积(Hct)、全血高切还原粘度、全血低切还原粘度指标。结果与T0相比,A、B、C组患者全血低、中、高切变率下全血粘度、血浆粘度、红细胞压积及红细胞变形指数在T1、T2时均有明显下降(P<0.05);T2与T1比较,A组低切变率全血粘度、红细胞压积、红细胞聚集指数指标升高,差异有统计学意义(P<0.05);T0时,3组的低、中、高切变率全血粘度、血浆粘度、红细胞压积、全血高切还原粘度、全血低切还原粘度、红细胞刚性指数及聚集指数比较差异均无统计学意义;T1和T2时,C组与A组相比,患者全血粘度、红细胞刚性指数及聚集指数指标均降低(P<0.05);T2时,B组与A组相比,患者低、中、高切变率全血粘度、血浆粘度、红细胞压积、全血高切还原粘度、全血低切还原粘度、红细胞刚性指数及聚集指数差异无统计学意义。结论不同剂量羟乙基淀粉输入均能有效改善结直肠癌手术患者血液流变学状态,20mL?kg-1羟乙基淀粉的疗效较优。

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