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胃癌组织中E-cadherin和MMP-9的表达及其临床意义

Keywords: 胃癌,E一钙粘素,基质金属蛋白酶-9

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Abstract:

目的探讨E-cadherin和MMP-9在胃癌组织中的表达,分析二者的相关性、与临床病理特征的关系及它们在胃癌浸润转移过程中的作用。方法用免疫组织化学染色方法分别检测E-cadherin和MMP-9在30例胃癌组织中及25例正常胃粘膜内的表达情况。结果E-cadherin在胃癌组织中和正常胃粘膜中阳性表达率分别为33.33%(10/30)和100%(25/25)。MMP-9在胃癌组织中和正常胃粘膜中阳性表达率分别为76.7%(23/30)和0.00%(0/25),胃癌组织中E-cadherin和MMP-9表达呈负相关(P<0.05)。结论胃癌组织E-cadherin的表达低而MMP-9的表达高,说明两者与胃癌的生物学行为密切相关,二者共同促进了胃癌的浸润与转移,因此,E-cadherin和MMP-9检测有助于胃癌恶性程度和侵袭能力的判断。

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