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莫西沙星对心衰合并CAP患者OT间期及QT离散度影响的分析

, PP. 220-222

Keywords: 莫西沙星,心衰,QTc,QTcd

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Abstract:

目的探讨莫西沙星对充血性心力衰竭合并社区获得性肺炎(CAP)患者QT间期及QT离散度的影响。方法将沈阳市胸科医院心血管科2009―2012年收治的116例充血性心功能衰竭(NYHAⅢ-Ⅳ级)合并CAP患者作为观察组应用常规剂量莫西沙星(400mg每日)治疗,116例心功能正常CAP患者作为对照组1应用常规剂量莫西沙星治疗,将116例充血性心功能衰竭(NYHAⅢ-Ⅳ级)合并CAP患者作为对照组2应用常规剂量β-内酰胺类或头孢类抗生素治疗,分析和比较观察组及对照组治疗前后QTc(校正的QT间期)及QTcd(校正的QT间期离散度)。结果使用常规剂量莫西沙星治疗可使单纯CAP患者QTc延长(15.5±6.1)ms,使充血性心力衰竭合并CAP患者QTc延长(48.2±5.3)ms;而应用β-内酰胺类或头孢类抗生素的心衰合并CAP患者,治疗前后QTc比较差异无统计学意义;单纯CAP和CAP合并心衰患者使用常规剂量莫西沙星治疗前后QTcd比较,差异也有统计学意义。结论莫西沙星对心衰合并CAP患者QT间期影响高于单纯CAP而心功能正常者,影响心衰患者QTcd的因素为心衰本身。心衰合并CAP患者应用莫西沙星更应慎重,应在严密监测心电图的基础上应用。

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