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组织蛋白酶在宫颈鳞癌中的表达及临床意义

DOI: 10.3969/j.issn.1674-6309.2005.03.006, PP. 185-187

Keywords: 宫颈鳞癌,Cath-D,慢性宫颈炎,子宫

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Abstract:

目的探讨组织蛋白酶(Cath-D)在宫颈鳞癌中的表达及其意义。方法〖HTSS〗应用免疫组化法检测31例宫颈上皮内瘤样病变(CIN)、71例宫颈浸润鳞癌组织(ICC)及23例正常子宫颈、慢性宫颈炎组织标本中Cath-D的表达。结果Cath-D在正常宫颈组织鳞状上皮基底层有少量弱阳性表达,表达率为21.74%;在CIN组中表达率为16.13%,与对照组比较无明显差异(P>0.05)。Cath-D在ICC组中表达率为54.93%,较对照组表达明显增加(P<0.05);在宫颈鳞癌中Cath-D总表达率为48.28%,且与组织分化程度显著相关(P<0.01),与淋巴结转移也明显相关(P<0.05)。结论Cath-D在宫颈鳞癌中有较高的表达率,组织分化程度越低、有淋巴结转移者,表达率越高。

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