Folkman J. What is the evidence that tumors are angiogenesis depen dent? [J]. J Natl Cancer Inst,1990,82(1):4-6.
[2]
Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endoth elial growth factor expression in gastric carcinoma [J]. Cancer, 1996,77(5):858-86 3.
[3]
Lee JC, Chow NH, Wang ST, et al. Prognostic value of vascular endothelia l gr owth factor expression in colorectal cancer patients [J]. Eur J Cancer, 2000 ,36(6):748-753.
[4]
Maeda H, Akaike T. Nitric oxide and oxygen radicals in infection, inflam mation and cancer[J]. Biochemistry, 1998,63(7):854-865.
[5]
Rosbe KW, Prazma J, Petrusz P, et al. Immunohistochemic alchar acteriza tion of nitric oxide synthase activity in squamous cell carcinoma of the head and ne ck[J]. Otolaryngol Head and Neck Surg, 1995,113(5): 541-549.
[6]
Thomsen LL, Miles DW, Happerfield L, et al. Nitric oxide synthase activi ty in human breast cancer[J]. Br J Cancer, 1995,72(1):41-44.
[7]
Goldstein SR, Yang GY, Chen X, et al. Studies of iron deposits, inducibl e ni tric oxide synthase and nitrotyrosine in a rat model for esophageal adenocarcino ma[J]. Carcinogenesis, 1998, 19(8): 1445-1449.
Jenkins DC, Charles IG, Thomsen LL. Roles of nitric oxide in tumor growt h proc[J]. Natl Acad Sci USA,1995,92(10):4392-4396.
[10]
Gallo O, Masini E, Morbidelli L, et al. Role of nitric oxide in angiogenesi s and tumor progression in head and neck cancer[J]. J Natl Cancer Insl,1998, 90(8):587-596.
[11]
Dvorak HF,Brown LF, Detmar M, et al. Vascular permeability factor/vascu lar endothelial grouth factor,microvascular hyper permeability,and angiogenesis[J] .Am J Pathol,1995,146(5):1029-1039.
[12]
Kondo S, Asano M, Matsuo K, et al. Vascular endothelial growth fac tor/vascula rperm iability factoris detectable in the sera of tumor-bearing mice and cancer patients[J].Biochim Biophys Acta, 1994,1221:211-214.
[13]
Kimura H,Weisz A,Kurashima Y,et al. Hypoxia response element of the hum an v ascular endothelial growth factor gene mediates transcriptional regulation by ni tric oxide:control of hypoxia-inducible factor-1 activity by nitric oxide [J] .Blood, 2000,95(1):189-197.
[14]
Hood JD, Meininger CJ, Ziche M, et al. VEGF upregulates eCNOS message, prot ein, and NO production in human endothelial cells [J]. Am J Physol, 1998, 274 (3pt2):H1054-H1058.