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血必净注射液对体外循环期间细胞因子TNF-α和IL-6的影响

, PP. 440-442

Keywords: 血必净注射液,体外循环,炎性反应综合征,细胞因子,TNF-α,IL-6?

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Abstract:

目的观察血必净注射液对体外循环(CPB)期间肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)的影响。方法选择30例心脏瓣膜置换术患者,随机分成实验组和对照组(每组15例)。实验组患者于术前晚、CPB前分别予血必净注射液100mL静滴,对照组予生理盐水静滴。于CPB前、CPB30min、CPB停机、停机后2h、6h、24h采用放射免疫法测定两组血清中TNF-α和IL-6的浓度。结果实验组TNF-α、IL-6血清浓度较对照组降低,差异有统计学意义(?P?<0?01)。结论血必净注射液能减少CPB期间TNF-α和IL-6的释放,减轻全身炎性反应的程度。?

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