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P504s、P63和Ck34βE12联合检测在前列腺腺癌鉴别诊断中的应

, PP. 434-436

Keywords: 前列腺腺癌,免疫组化,诊断,P504s,P63,Ck34βE12

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Abstract:

目的探讨P??504s?、P??63?和Ck??34?βE??12?联合免疫组化染色在前列腺良、恶性病变鉴别诊断中的价值。方法采用免疫组织化学方法观察P??504s?、P??63?、Ck??34?βE??12?和PSA在82例不同前列腺疾病中的表达情况。结果在18例前列腺腺癌中P??63?、Ck??34?βE??12?染色均(-),17例P??504s?呈(+);良性前列腺增生及低度前列腺上皮内瘤(PIN)的腺泡和导管周围可见连续的P??63?和Ck??34?βE??12?(+),少数呈间断表达,但P??504s?染色皆呈(-);PIN,P??63?和Ck??34?βE??12?染色基底细胞呈不连续表达或(-);而增生的腺上皮,部分细胞P??504s?呈弱(+);非典型腺瘤性增生P??63?和Ck??34?βE??12?呈(+),P??504s?呈(-)。PSA在所有病例中均强阳性表达。结论P??504s?对判断前列腺腺癌具有重要参考价值;P??504s?、P??63?和Ck??34?βE??12?联合检测可提高前列腺癌诊断的正确率;PSA对前列腺组织有极高的敏感性,但在良、恶性病变鉴别诊断中意义不大。

References

[1]  Jiang Z,Woda BA,Rock KL,et al?P??504s?:a new molecular marker for the detection of prostate carcinoma[J]. Am J Surg Pathol,2001,25:1397-1404??
[2]  Zhou M,Jiang Z? Expression and diagnostic utility of alpha?methylacyl- COA ra cemase(P??504s?)in foamy gland and pseudohyperplastic prostate cancer[J]. A m J Surg Pathol,2003,27:772-778
[3]  Xu J,Stolk JA,Zhang X,et al? Identification of differentially e xpressed ge nes in human prostate cancer using subtraction and microarry[J]. Cancer Res, 2000,60:1677-1682??
[4]  Mostofi FK,Sesterhenn IA,Davis CJ,et al? Histological typing of prost ate tumours[C]? WHO,Geneva? Heideberg:springer,2002:?
[5]  Beach R,Coun AM,De peralta-Venturina MN,et al? P??504s? immunohist ochemistry detection in 405 prostatic specimens including 376 18 gauge needle biopsies[J] . Am J Surg Pathol,2002,26:1588-1596??
[6]  Magi-Galluzzi C,Luo J,Isaacs WB,et al? Alpha-methylacyl-COA racemase :a ve riably sensitive Immunohistochemistry marker for the diagnosis of Smail Prostate cancer foci on needle biopsy[J]. Am J Surg Pathol,2003,27:1128-1133??
[7]  陈光勇,孙丽娜,周小鸽,等?α-甲酰基辅酶A消旋酶在前列腺腺癌诊断和鉴别诊 断中的作用[J].中华病理学杂志,2004,10(5):419-423??
[8]  Chen L,Jiang,wode BA? Decreased expression of alphametrlacy-COA racema se/ P??504s? in foamy gland carcinoma of the prostate[J]. Mod Pathol,2003,16 :145A??

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