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还原型谷胱甘肽干预高同型半胱氨酸血症 致兔动脉粥样硬化的实验研究

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Keywords: 还原型谷胱甘肽,高同型半胱氨酸血症,动脉粥样硬化

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Abstract:

目的探讨还原型谷胱甘肽干预高同型半胱氨酸血症致兔动脉粥样硬化的机制。方法将44只新西兰白兔随机分为4组对照组以标准饲料100g?d-1喂养,模型组以1%蛋氨酸饲料100g?d-1喂养,低剂量药物组以1%蛋氨酸饲料100g?d-1喂养+还原型谷胱甘肽15mg?d-1肌注,高剂量药物组以1%蛋氨酸饲料100g?d-1喂养+还原型谷胱甘肽30mg?d-1肌注。于实验前和实验8周后耳中央动脉采血检测Hcy、TC、TG、CRP、SOD并对结果进行分析。结果模型组Hcy水平高于对照组,差异有统计学意义(P<0.05);模型组SOD活性降低,与对照组比较差异有统计学意义(P<0.05);模型组CRP值高于对照组,差异有统计学意义(P<0.05);经还原型谷胱甘肽治疗,模型组IMT高于对照组(P<0.05);低剂量药物干预组IMT较对照组有所增厚(P<0.05);高、低剂量药物干预组IMT与模型组比较,差异有统计学意义(P<0.05)。结论还原型谷胱甘肽通过抑制氧化应激、炎症反应阻止动脉粥样硬化的发生、发展。

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