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瘦素基因启动子G-2548A多态性与青年高血压的相关性研究

, PP. 603-605

Keywords: 高血压,青年人,瘦素基因,多态性

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Abstract:

目的探讨瘦素基因多态性与青年人高血压的相关性。方法采用PCR-RFLP技术对98例青年高血压患者、105例青年血压正常者和86例老年高血压者的瘦素基因G-2548A位点多态性进行研究,并分析比较三组人群该基因基因型及等位基因的分布。结果青年高血压组AG/GG基因型频率和G等位基因频率明显高于青年正常对照组(P<0.05);青年高血压组AG/GG基因型频率和G等位基因频率明显高于中老年高血压病例组(P<0.05)。结论青年高血压组G等位基因频率明显高于青年正常组和中老年高血压组,瘦素基因启动子G-2548A多态性可能与青年人高血压存在关联。

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