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瑞芬太尼预处理对 急性失血性休克家兔心肌肌钙蛋白I及心率的影响

, PP. 575-578

Keywords: 瑞芬太尼,失血性休克,预处理,心肌钙蛋白I

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Abstract:

目的观察瑞芬太尼预处理对急性失血性休克家兔心肌肌钙蛋白I及心率的影响。方法24只家兔随机均分为三组生理盐水对照组(C组,n=8)、低剂量瑞芬太尼组(R1组,n=8)、高剂量瑞芬太尼组(R2组,n=8)。按照Wigger's改良法制作家兔急性失血性休克模型。R1组、R2组分别于放血前15min开始持续泵入瑞芬太尼0.66μg?kg-1?min-1或1.32μg?kg-1?min-1;C组持续泵入等容量生理盐水。放血使平均动脉压(MAP)降至约40mmHg。持续监测心率(HR)、MAP。各组分别在放血前(T1)、放血后10(T2)、40(T3)、70(T4)、100(T5)、130(T6)min抽血测定血清心肌肌钙蛋白I(cTnI)浓度。结果与基础心率T0比较,休克期间,各组心率随着时间的推移,逐渐下降(P<0.05);与C组比较,R2组心率下降(P<0.05)。与T1时比较,T4、T5、T6时各组的cTnI浓度均升高(P<0.05),R2组T3时cTnI浓度已高于T1(P<0.05)。R1组和R2组cTnI浓度均明显低于C组(P<0.05)。R2组T5、T6时的cTnI浓度均低于R1组(P<0.05)。结论瑞芬太尼可剂量依赖性地使急性失血性休克家兔心率减慢,血清cTnI浓度降低,此效应可能与其心肌保护作用有关。

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