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Claudin-2在大肠癌中的表达及其与临床病理特征的关系

, PP. 600-602

Keywords: 紧密连接蛋白,大肠癌,免疫组织化学

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Abstract:

目的观察紧密连接蛋白Claudin-2在大肠癌组织中的表达及其与大肠癌发生和发展的关系。方法运用免疫组化技术检测Claudin-2在大肠癌及癌旁组织、正常组织中的表达,并分析Claudin-2蛋白表达与大肠癌临床各病理特征的关系。结果Claudin-2在大肠癌组织中的阳性表达率明显高于癌旁组织及正常组织(P<0.05)。Claudin-2在大肠癌组织中的阳性表达与肿瘤的分化程度、Dukes分期密切相关(P<0.05)。结论大肠癌与癌旁组织及正常组织相比,Claudin-2表达阳性率明显升高,其改变在大肠癌的发生发展中可能起重要作用。

References

[1]  Peto J. Cancer epidemiology in the last century and the next decade[J]. Nature,2001,411:390- 395.
[2]  Tsukuma H, Ajiki W. Descriptive epidemiology of colorectal can-cer-international comparison[J]. Nippon Rinsho,2003,61:25- 30.
[3]  王继恒,李世荣.我国结直肠癌筛查和早期诊断十年回顾:1994-2005 [J].胃肠病学, 2006, 11(4):245-250.
[4]  HeiskalaM, Peterson PA,Yang Y.The roles of claudin superfamily proteins in paracellular transport[J].Traffic, 2001, 2(2): 93-98.
[5]  Kominsky SL, Argani P, Korz D, et al. Loss of the tight junction protein claudin27 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast[ J ]. Oncogene, 2003, 22(13): 2021.
[6]  Kominsky SL. Claudins: emerging targets for cancer therapy [J]. Expert Rev Mol Med,2006, 8(18): 1- 11.
[7]  Laural Mitic, Christina M, Van Itallie,et al. MolecularPhysiol-ogy and Pathophysiology of Tight Junctions I. Tight junction structure and function: lessons from mutant animals and proteins[J]. Am J Physiol Gastrointest Liver Physiol, 2000, 279(2):G250-G254.
[8]  Montgomery E, Mamelak AJ, Gibson M, et al. Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions[J].Appl Immunohistochem Mol Morphol, 2006,14:24-33.
[9]  Kominsky SL, Vali M, Korz D, et al. Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4[J]. Am J Pathol, 2004,164:1627-1633.
[10]  Soini Y. Expression of claudins 1,2,3,4,5 and 7 in various types of tumours[J]. Histopathology,2005, 46: 551-560.

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