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Syndecan-1和E-cadherin在子宫内膜癌组织中的表达及意义

, PP. 190-193

Keywords: 免疫组化法,子宫内膜癌,Syndecan-1,E-cadherin

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Abstract:

目的检测子宫内膜癌中Syndecan-1和E-cadherin的表达情况,以探讨Syndecan-1和E-cadherin与子宫内膜癌的发生发展、浸润和转移的关系。方法采用免疫组化法检测Syndecan-1和E-cadherin在56例子宫内膜癌、20例正常子宫内膜组织和20例不典型增生子宫内膜组织中的表达。结果Syndecan-1和E-cadherin在子宫内膜癌、不典型增生子宫内膜和正常子宫内膜组织的强阳性表达率分别为71.43%、45.00%、30%和41.07%、70.00%、85.00%,表达率差异有统计学意义(P0.05),与子宫内膜癌的组织学分级、有无肌层浸润和临床分期有关(P0.05),与子宫内膜癌的组织学分级、临床分期有关(P<0.05)。结论Syndecan-1的表达上调与E-cadherin表达下调在子宫内膜癌侵润转移中起着重要作用,联合检测Syndecan-1和E-cadherin在子宫内膜癌的表达,可能有助于从多方面了解子宫内膜癌的恶性程度。

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