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胃癌组织EGFR、C-erbB-2表达及其意义

Keywords: 胃癌,EGFR,C-erbB-2

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Abstract:

目的探讨EGFR与C-erbB-2表达及病理学特征与胃癌患者术后生存的关系。方法应用免疫组织化学方法对64例随访资料完整的胃癌标本行EGFR与C-erbB-2检测,结合病理学特征对患者3年生存期进行分析。结果Kaplain―Meier分析显示,胃癌患者的病理分级、浸润深度、TNM分期、淋巴结转移及EGFR与C-erbB-2是影响患者预后的重要因素(P<0.05);Cox回归多因素模型分析显示,肿瘤的病理分级Exp(B)=3.678,TNM分期Exp(B)=3.428与C-erbB-2Exp(B)=5.426表达是独立预后因素,其中以TNM分期与C-erbB-2表达最为重要。结论TNM分期、C-erbB-2表达是独立的预后因素,其中C-erbB-2高表达是危险因素。

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