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脑梗死患者雌激素水平与阿司匹林抵抗的关系

, PP. 1016-1019

Keywords: 绝经,雌二醇,脑梗死,阿司匹林抵抗,血小板聚集

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Abstract:

目的探讨绝经后脑梗死患者阿司匹林抵抗与雌激素水平的关系。方法74例绝经后脑梗死患者和52例未绝经脑梗死女性患者每日口服肠溶阿司匹林100mg,28d后分别测定花生四烯酸(ArachidonicAcid,AA)和二磷酸腺苷(AdenosineDiphosphate,ADP)诱导的血小板聚集率和血清雌二醇浓度。以血小板聚集率AA≥20%和(或)血小板聚集率ADP≥70%为标准,符合一项为阿司匹林半抵抗(AspirinSemiResistance,ASR),均符合为阿司匹林抵抗(AspirinResistance,AR),均不符合为阿司匹林敏感(aspirinsensitive,AS)。比较两组患者血清雌二醇和阿司匹林敏感程度的差别,以及各因素间是否存在相关性。结果绝经后脑梗死组AR和ASR的发生率分别为5.4%和25.7%,而未绝经脑梗死组AR和ASR的发生率为1.9%和15.4%,绝经后脑梗死组阿司匹林抵抗率(31.1%)高于未绝经组(17.3%),χ2=4.40,P<0.05。两组相比,绝经后脑梗死组血清雌二醇显著降低、AR和ASR的发生率显著升高(P<0.05)。结论绝经后女性更易发生阿司匹林抵抗,其发生与雌激素水平降低有关。

References

[1]  Antithrombotic Trialists'(ATT)Collaboration, Baigent C, Blackwell L, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials [J]. Lancet, 2009, 373(9678):1849-1860.
[2]  Wang TH, Bhatt DL, Topol EJ. Aspirin and clopidogrel resistance: an emerging clinical entity [J]. Eur Heart J,2006,27(6): 647-654.
[3]  韩玲, 张均. 绝经后血浆雌激素水平与脑梗死的关系[J]. 中国实用神经疾病杂志, 2009,12(6):33-34
[4]  Fitzgerald R, Pirmohamed M. Aspirin resistance: effect of clinical, biochemical and genetic factors[J]. Pharmacol Ther,2011,130(2):213-225.
[5]  Patrono C, Rocca B. Aspirin: promise and resistance in the new millennium [J]. Arterioscler Thromb Vasc Biol,2008, 28(3): s25-s32.
[6]  Schwartz KA, Schwartz DE, Barber K, et al. Non-compliance is the predominant cause of aspirin resistance in chronic coronary arterial disease patients[J]. J Transl Med, 2008,6:46.
[7]  Kasotakis G, Pipinos II, Lynch TG. Current evidence and clinical implications of aspirin resistance [J]. J Vasc Surg,2009, 50(6): 1500-1510.
[8]  Cuisset T, Frere C, Quilici J, et al. Aspirin noncompliance is the major cause of “aspirin resistance” in patients undergoing coronary stenting[J]. Am Heart J,2009, 157(5):889-893.
[9]  Spektor G, Fuster V. Drug insight: cyclo-oxygenase 2 inhibitors and cardiovascular risk-where are we now? [J]. Nat Clin Pract Cardiovasc Med,2005,2(6):290-300.
[10]  Kour D, Tandon VR, Kapoor B, et al. Aspirin Resistance [J]. JK Science,2006,8(2):116-117.
[11]  Bauriedel G, Skowasch D, Schneider M, et al. Antiplatelet effects of angiotensin-converting enzyme inhibitors compared with aspirin and clopidogrel: a pilot study with whole-blood aggregometry[J]. Am Heart J,2003, 145(2):343-348.
[12]  Reavey-Cantwell JF, Fox WC, Reichwage BD, et al. Factors associated with aspirin resistance in patients premedicated with aspirin and clopidogrel for endovascular neurosurgery [J]. Neurosurgery, 2009,64(5):890-895.
[13]  Kovanen PT, Pentikainen MO. Pharmacologic prevention of coronary plaque rupture-the major cause of acute coronary syndromes [J]. Heart Metab,2007,36:9-14.
[14]  Kunicki TJ, Williams SA, Nugent DJ, et al. Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease[J]. Thromb Haemost,2009,101(1):123-133.
[15]  王晓鹏,李春岩,耿连霞,等.性激素水平与脑梗死及相关因素关系的研究[J]. 脑与神经疾病杂志, 2003, 11(3):158-160.
[16]  薛新宏, 王大力, 尚淑玲,等. 雌激素对大鼠脑缺血再灌注后自由基含量的影响[J]. 第四军医大学学报, 2009,30(4):封2.

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