全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

缺血性小血管病与血管性痴呆的相关性研究

, PP. 252-256

Keywords: 多发性腔隙性脑梗死,白质病变,血管性痴呆

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的探讨缺血性小血管病(SVD),包括多发性腔隙性脑梗死(MLI)和脑白质病变(WML)与血管性痴呆(VD)的关系。方法采用简易精神量表(MMSE)和蒙特利尔认知评估量表(MoCA)对90例经颅脑CT或颅脑MRI证实的SVD患者(单纯MLI组、MLI+WML组、单纯WML组)和23例非SVD患者进行检测并分析比较。结果(1)MMSE评分显示,与对照组比较,单纯MLI组即刻记忆、短程记忆、物体命名、语言复述、阅读理解、言语表达的分值均降低(均P0.05)。单纯MLI组与MLI+WML组比较,阅读理解分值降低(P0.05)。(4)单纯WML组与对照组Logistic回归显示高血压病史(P=0.045,OR=5.158)、糖尿病病史(P=0.032,OR=0.049)与脑白质病变相关,其中高血压病史对脑白质病变影响大。结论缺血性小血管病变可导致痴呆,主要表现在时间定向、地点定向、即刻记忆等亚项。三组中MLI+WML组的痴呆发生率最高。对于脑白质病变,高血压对其影响最大。

References

[1]  解恒革,王晓红,王振福,等.简短智力状态检查在老年人轻度认知损伤检查中的应用[J].中国临床康复,2002,6:2844-2845.
[2]  Nasreddine ZS,Phillips NA,Bédirian V,et al.The Montreal Cognitive Assessment(MoCA):A Brief Screening Tool For Mild Cognitive Impairment[J].J Am Geriatr Soc,2005,53:695?699.
[3]  全国脑血管病学术会议.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379.
[4]  Kinkel WR, Jacobs L, Polachini I, et al. Subcortical arteriosclerotic encephalopathy(Binswanger's disease)[J]. Arch Neurol,1985,42(10):951-959.
[5]  Ishii S, Shishido F, Miyajima M, et al. Comparison of Alzheimer's Disease with Vascular Dementia and non-De-mentia Using Specific Voxel-Based Z Score Maps[J]. Ann Nucl Med(S0914-7187),2009,23(1):25-31.
[6]  王敏.血管性痴呆的临床进展[J].中国医师杂志,2006,29(增刊):429.
[7]  李华,徐格林,赵文新,等.脑小血管病变[J].国际脑血管病杂志,2006,14(11):831-835.
[8]  Román GC, Erkinjuntti T, Wallin A,et al, Subcortical ischaemic vascular dementia[J].Lancet Neurol,2002,426-436.
[9]  朱以诚,高山,刘秀琴,等.轻-中度血管性痴呆患者的头部影像学与认知功能障碍的关系[J].中华老年心脑血管病杂志,2000,2(5):315-317.
[10]  王红梅,杨丽丽,白玉海,等.血管性痴呆的研究进展[J].齐齐哈尔医学院学报,2009,30(10):1226-1228.
[11]  Enon H,Durieu I,Guerouaou D,et al.Poststroke dementia:incidence and relationship to prestroke cognitive decline[J].Neurology,2001,57:1216.
[12]  Valentine AR, LF Moseley, BE Kendall. White matter abnormality in cerebral atrophy: clinicoradiological correlations[J].J Neurol Neurosurg Psychiatry, 1980, 43:139-142.
[13]  Launer LJ, K Berger MM, Breteler, et al. Regional variability in the prevalence of cerebral white matter lesions: an MRI study in 9 European countries(CASCADEI)[J].Neuroepidemiology,2006, 26: 23-29.
[14]  Wright CB, Festa JR, Paik MC, et al. White matter hyperintensities and suclinical infarction:associations with psychomotor speed andcognitive flexibility[J].Stroke,2008,39: 800-805.
[15]  Delano-Wood L, Abeles N, Sacco JM, et al.Regional white matter pathology in mild cognitive impairment: differential influence of lesion type on neuropsychological functioning[J].Stroke, 2008,39:794-799.
[16]  [16 ] Sachdev PS, Brodaty H, Valenzuela MJ, et al.Clinical determinants of dementia and mild cognitive impairment following ischaemic stroke: the Sydney stroke study[J]. Dement Geriatr Cogn Disord,2006,21:275-283.
[17]  RomanGC, TatemichiTK, ErkinjunttiT et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN InternationalWorkshop[J].Neurology, 1993, 43:250.
[18]  Roman GC, Erkinjuntti T, Wallin A, et al. Subcortical ischemic vascular dementia[J].LacetNeurology,2002,1(7):426-436.
[19]  连岗.多发性腔隙性脑梗塞并发痴呆有关因素探讨[J].浙江临床医学,2002,4(4):297.
[20]  De Leeuw FE, BarkhofF. Scheltens Progression of cerebralwhitematter lesions inAlzheimer's disease: a newwindow for therapy[J].J Neurol Neurosurg Psychiatry, 2005,76: 1286-1288.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133