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CYP1A1 rs4646903 单核苷酸多态性 与宁夏地区男性不育相关性研究

, PP. 208-210

Keywords: 男性不育,细胞色素p4501A1,单核苷酸多态性

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Abstract:

目的分析CYP1A1(rs4646903,T/C)单核苷酸多态性与宁夏地区男性不育的相关性。方法采用病例-对照研究方法,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术分别对204例男性不育患者和202例正常男性对照的CYP1A1rs4646903单核苷酸多态性进行测定,分析基因型及等位基因频率在患者组和对照组的分布特点。结果相对于纯合野生基因型TT,未见CYP1A1rs4646903杂合突变型TC(OR=1.07,95%CI=0.70~1.65)和纯合突变型CC(OR=1.41,95%CI=0.79~2.50)与男性不育有关联(P>0.05)。此外,相对于野生基因T,也未见突变基因C与男性不育有关联(OR=1.17,95%CI=0.88~1.55)。结论CYP1A1rs4646903单核苷酸多态性与宁夏地区男性不育无相关性。

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