CA125和CA199检测对卵巢上皮癌的诊断价值

目的探讨血清CA125和CA199检测对卵巢上皮癌的临床价值。方法卵巢上皮癌患者68例及卵巢上皮类良性肿瘤患者32例术前进行血清CA125、CA199测定;卵巢上皮癌患者每次化疗前复查血清CA125、CA199,以CA125和CA199检测任何一项阳性视为联合检测阳性统计。结果CA125检测的敏感度为77.9%,特异度为93.8%;CA199检测的敏感度为41.2%,特异度为96.9%;联合检测敏感度为92.6%,特异度为90.6%;血清CA125对卵巢浆液性囊腺癌和粘液性囊腺癌的灵敏度分别为93.8%和36.8%;CA199为24.5%和84.2%;Ⅲ+Ⅳ期卵巢上皮癌患者的CA125和CA199明显高于I+Ⅱ期患者;术后血清CA125、CA199值未降至正常或降至正常后又升高者预后不良或复发。结论血清CA125和CA199是卵巢上皮癌诊断和判断预后的敏感性指标,CA125对卵巢浆液性癌较敏感,CA199对卵巢粘液性癌较敏感,二者联合检测可提高诊断的敏感性和特异度。