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华西医学  2011 

含益生元膳食纤维的早期肠内营养用于腹部外科术后的随机对照研究

, PP. 1327-1330

Keywords: 益生元,膳食纤维,肠道菌群,腹部外科

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Abstract:

【】 目的 探讨强化益生元膳食纤维的肠内营养在腹部外科术后患者中的临床应用。 方法 2008年7月-2010年11月30例接受腹部外科中等以上手术的患者术前随机分为研究组和对照组,每组15例。研究组患者于术后接受肠内营养,并予以强化益生元膳食纤维;对照组只接受相同的肠内营养支持。观察指标为术后感染并发症、胃肠道并发症、住院时间、抗生素治疗时间、C反应蛋白水平和病死率等。 结果 研究组术后住院时间为(10±5)d,对照组为(15±7)d,两组差异有统计学意义(t=2.251,P=0.033);研究组C反应蛋白水平为(6.6±3.2)mg/L,对照组为(9.8±2.1)mg/L,两组差异有统计学意义(t=3.238,P=0.003);研究组抗生素治疗时间为(5.0±3.5)d,对照组为(6.0±4.8)d,两组差异无统计学意义(t=0.652,P=0.520)。两组均无死亡病例;术后研究组2例发生感染并发症,对照组3例,两组感染并发症发生率差异无统计学意义(P=1.000)。两组患者均能耐受经肠内补充营养素。 结论 与常规肠内营养比较,给予强化益生元膳食纤维的肠内营养能减少腹部外科术后患者的住院时间,降低急性期炎症反应。【Abstract】 Objective Toinvestigatetheeffectofearlyenteralsupplyofprebioticfiberinpatientsundergoingmajorabdominalsurgery. Methods BetweenJuly2008andNovember2010,30patientsundergoingmajorgastrointestinalsurgerywererandomizedintothestudygroupandthecontrolgroupbeforeoperationwith15patientsineachgroup.Prebioticfiberwasadministeredcombinedwithenteralnutritionsupportforpatientsinthestudygroup.Patientsinthecontrolgrouponlyreceivedconventionalenteralnutritionwithoutfiber.Themainendpointsincludedthedevelopmentofbacterialinfection,thedurationofhospitalstay,antibiotictherapy,theserumlevelofC-reactionprotein(CRP),sideeffectsoftheenteralnutritionandmorbidity. Results Comparedwiththecontrolgroup,themediandurationofhospitalstaywasshorterinthestudygroup(15±7)daysinthecontrolgroupvs.(10±5)daysinthestudygroup;t=2.251,P0.05).Nopatientsdiedinboththetwogroups. Conclusion Comparedwiththeconventionalenteralnutrition,earlyenteralsupplyofprebioticfibercanreducethedurationofhospitalstayandacutephaseresponse.

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