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华西医学  2011 

瑞舒伐他汀对慢性肾病患者抗炎作用的临床观察

, PP. 1287-1289

Keywords: 瑞舒伐他汀,慢性肾病,炎症

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Abstract:

【】 目的 探讨瑞舒伐他汀对慢性肾病患者抗炎疗效。 方法 选取2009年11月-2010年12月90例慢性肾病患者,随机分为A、B两组,A组50例,给予瑞舒伐他汀钙10mg/d;B组40例,给予阿托伐他汀钙10mg/d,两组患者的年龄和性别相匹配。分别测定其治疗前及治疗后12周时血白细胞、高敏反应蛋白、纤维蛋白原、白介素-6、肿瘤坏死因子-α。 结果 两组治疗前各炎症指标水平差异无统计学意义(P>0.05)。与治疗前相比,两组患者治疗12周后炎症指标水平均较前明显下降(P0.05).Theinflammatorymarkerlevelsoftwogroupsaftertreatmentfor12weeksweresignificantlydecreasedcomparedwiththelevelsbeforetreatment(P<0.01),androsuvastatincalciumgroupdecreasedmoreapparentlythanatorvastatincalciumgroup. Conclusion Rosuvastatincanimprovetheanti-inflammatoryresponseinCKDpatients.

References

[1]   Wanner C, Zimmermann J, Schwedler S, et al. Inflammation and cardiovascular risk in dialysis patients[J]. Kidney Int, 2002, 18(8): 1452-1455.
[2]   Dimitrow PP, Jawie? M. Anti-inflammatory effect of atorvastatin in patients with aortic sclerosis or mild aortic stenosis independent of hypercholesterolemia[J]. Pharmacological Rep, 2010, 62(6): 1250-1254.
[3]   M?rz W, Genser B, Drechsler C, et al. Atorvastatin and low-density lipoprotein cholesterol in type 2 diabetes mellitus patients on hemodialysis[J]. Clin J Am Soc Nephrol, 2011, 6(6): 1316-1325.
[4]   Her AY, Kim JY, Kang SM, et al. Effects of atorvastatin 20 mg,rosuvastatin 10 mg, and atorvastatin/ezetimibe 5 mg/5 mg on lipoproteins and glucose metabolism[J]. J Cardiovasc Pharmacol Ther, 2010, 15(2): 167-174.
[5]   Shlipak MG, Fried LF, Crump C, et al. Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency[J]. Circulation, 2003, 107(1): 87-92.
[6]   Recio-mayoral A, Banerjee D, Streather C, et al. Endothelial dysfunction, inflammation and atherosclerosis in chronic kidney disease:a cross-sectional study of predialysis, dialysis and kidney-transplantation patients[J]. Atherosclerosis, 2011, 216(2): 446-451.
[7]   Zyga S, Christopoulou G, Malliarou M. Malnutrition-inflammation-atherosclerosis syndrome in patients with end-stage renal disease[J]. J Ren Care, 2011, 37(1): 12-15.
[8]   Michel C, Giuseppe L, Martina M, et al. Association of inflammation with anaemia in patients with chronic kidney disease not requiring chronic dialysis[J]. Nephrol Dial Transplant, 2008, 23(9): 2879-2883.
[9]   Ross R. Atrheroselerosis-an inflammatory disease[J]. N Engl J Med, 1999, 340(2): 115-126.
[10]   王海燕. 肾脏病学[M]. 3版. 北京: 人民卫生出版社, 2008: 1886-1892.
[11]   Goldsmith D, Covic AC. Jupiter or Aurora Micro-inflammation and dyslipidaemia: twin targets for statin therapy in CKD[J]. Int Urol Nephrol, 2010, 42(1): 133-136.
[12]   李秋荣, 王勤, 曲环, 等. 瑞舒伐他汀对血脂正常的2型糖尿病患者血清高敏C反应蛋白的作用[J]. 中华高血压杂志, 2011, 19(3): 280-282.
[13]   严庆场, 吴广华. 瑞舒伐他汀对急性冠脉综合征患者CRP, LOX-1的影响[J].中华全科医学, 2011, 9(4): 581-632.
[14]   Burmeister JE, Miltersteiner DR, Campos BM. Rosuvastatin in hemodialysis: short-term effects on lipids and C-reactive protein[J]. J Nephrol, 2009, 22(1): 83-89.
[15]   Verma A, Ranganna KM, Reddy RS, et al. Effect of rosuvastatin on C-reactive protein and renal function in patients with chronic kidney disease[J]. Am J Cardiol, 2005, 96(9): 1290-1292.
[16]   Gómez-García A, Martínez Torres G, Ortega-Pierres LE, et al. Rosuvastatin and metformin decrease inflammation and oxidative stress in patients with hypertension and dyslipidemia[J]. Rev Esp Cardiol, 2007, 60(12): 1242-1249.
[17]   Ridker PM, Danielson E, Fonseca FA, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein[J]. N Engl J Med, 2008, 359(21): 2195-2207.
[18]   Qu HY, Xiao YW, Jiang GH, et al. Effect of atorvastatin versus rosuvastatin on levels of serum lipids, inflammatory markers and adiponectin in patients with hypercholesterolemia[J]. Pharm Res, 2009, 26(4): 958-964.

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