腺苷蛋氨酸治疗慢性乙型肝炎高胆红素血症

【】　目的　分析腺苷蛋氨酸治疗慢性乙型肝炎高胆红素血症的临床疗效。　方法　回顾性分析2010年1-12月28例接受腺苷蛋氨酸（2000mg静脉滴注，1次/d）治疗慢性乙型肝炎高胆红素血症患者的临床资料，并对腺苷蛋氨酸治疗慢性重症乙型肝炎高胆红素血症后症状、体征及实验室检测指标的改变情况进行总结，利用多因素logistic回归分析方法探索与疗效相关的预测因素。根据相关症状、体征和实验室结果的不同，将疗效分为显效、有效和无效3类。　结果　28例患者使用腺苷蛋氨酸治疗4周后，显效20例（71.4%），有效4例（14.3%），无效4例（14.3%）。多因素logistic回归分析提示病程短、并发症少是影响腺苷蛋氨酸疗效的独立预测因素。　结论　腺苷蛋氨酸是治疗慢性乙型肝炎高胆红素血症有效，发病时间短及并发症少的患者退黄效果更好。【Abstract】　Objective　ToinvestigatethecurativeefficacyofademetionineinthetreatmentofhyperbilirubinemiaforchronichepatitisBpatients.　Methods　Theclinicaldataof28chronichepatitisBpatientswithintrahepaticcholestasisreceivingintravenousademetioninetreatment(2000mgperday)wereretrospectivelyanalyzed.Patients’symptoms,bodysignsandlaboratoryexaminationresultsweresummarized,andpredictorsforefficacywereinvestigatedusingmultipleregressionanalysis.Inthisstudy,thecurativeefficacywasclassifiedintoremarkableefficacy,efficacyandinefficacy,accordingtotheclinicaldata.　Results　Afterone-monthtreatmentwithademetionine,thepercentageforremarkableefficacy,efficacyandinefficacywas71.4%,14.3%,and14.3%respectively.Multivariatelogisticregressionanalysisshowedthatshortdiseasedurationandfewercomplicationswereindependentpredictorsforremarkableefficacyofademetioninetreatment.　Conclusion　AdemetionineisaneffectiveagentforthetreatmentofhyperbilirubinemiainchronichepatitisBpatients,andtheresultisespeciallygoodforpatientswithshortdurationandfewercomplications.