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华西医学  2011 

Livin和Caspase-3在结直肠腺瘤-癌序列中的表达及相关性研究

, PP. 878-881

Keywords: Livin,Caspase-3,结直肠腺瘤,结直肠癌

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Abstract:

【】 目的 探讨凋亡抑制蛋白Livin与凋亡蛋白Caspase-3在结直肠腺瘤-癌序列中的表达变化及其相关性。 方法 2006年7月―2009年12月,采用免疫组织化学染色链霉菌抗生物素蛋白-过氧化物酶链接法streptavidin-peroxidese,SP)法检测18例正常黏膜、84例结直肠腺瘤、72例结直肠癌中Livin及Caspase-3的表达情况。 结果 结直肠腺瘤组织中Livin蛋白的阳性表达率明显高于正常黏膜组织(P0.05)。Livin表达与Caspase-3表达呈负相关(P0.05).LivinexpressionhadnegativecorrelationwiththeCaspase-3expression(P>0.05). Conclusion ThedifferenceinexpressionofLivinbetweenadenomaandadenocarcinomaindicatesthepotentialvalueofitincarcinogenesisofcolorectalcancer,whichsuggestesthatsuppressingCaspase-3proteinactivityisoneofthechannelsbywhichlivinpromotescolorectalcarcinogenesis.

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