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华西医学  2011 

肾移植术后牙龈增生的临床分析

, PP. 695-697

Keywords: 肾移植,环孢素A,牙龈增生,口腔卫生

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Abstract:

【】 目的 探讨肾移植术后药物(环孢素A和钙离子拮抗剂)、口腔卫生与牙龈增生的关系。 方法 随访2003年1月―2010年3月间321例肾移植患者,记录患者术后药物使用和口腔卫生情况,观察牙龈增生程度。结果 〖HTSS〗口腔卫生水平与牙龈增生程度之间存在统计学相关性(?r?s?=0.344,P=0.000),口腔卫生水平越差,牙龈增生越严重。服用环孢素A和钙离子拮抗剂患者(A组)牙龈增生发生率为62.15%,高于单纯服用环孢素A患者(B组)23.40%,二者比较,差异有统计学意义(χ2=39.220,P=0.000)。结论 〖HTSS〗肾移植术后环孢素A和钙离子拮抗剂联合应用明显增加了牙龈增生的发病率。口腔卫生水平与牙龈增生程度之间存在重要关联,口腔卫生差是牙龈增生的危险因素。【Abstract】 Objective Toinvestigatethecorrelationbetweendrugs(cyclosporineAandcalciumchannelblocker),oralhygieneandgingivalhyperplasiainpatientsafterrenaltransplantation. Methods Wecontinuouslyfollowedup321patientsundergoingrenaltransplantationfromJanuary2003toJuly2009inourhospital.Thelevelsoforalhygiene,medicationandgingivalhyperplasiawererecorded. Results Therewasacloserelationshipbetweentheleveloforalhygieneandthedegreeofgingivalhyperplasia(r?s=0.344,P=0.000).Highergradesofgingivalhyperplasia(gradesⅡandⅢ)werefoundexclusivelyinpatientswhodidnothavegoodoralhygiene.TherewasahighertendencyofdevelopinggingivalhyperplasiaamongpatientswhoreceivedcyclosporineAandcalciumchannelblockerthanthosewhoonlyreceivedcyclosporineA(62.15%vs.23.40%;χ2=39.220,P=0.000). Conclusion TheprevalenceofgingivalhyperplasiaishigherinrenaltransplantrecipientstakingcyclosporineAandcalciumchannelblockers.Thereisasignificantrelationshipbetweentheleveloforalhygieneandthedevelopmentofgingivalhyperplasia.Poororalhygieneisariskfactorofgingivalhyperplasia.

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