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华西医学  2011 

RhoA/Rho相关卷曲螺旋形成的蛋白激酶信号通路与慢性肾脏疾病

, PP. 781-783

Keywords: RhoA/ROCK信号通路,慢性肾脏疾病,肾间质纤维化,糖尿病肾病

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Abstract:

【】 RhoA/Rho相关卷曲螺旋形成的蛋白激酶(ROCK)信号通路是细胞内重要的信号转导通路,在慢性肾脏疾病的进展中起重要作用。肾间质纤维化是各种慢性肾脏疾病发展到终末期肾衰竭的共同途径;糖尿病肾病是继发性慢性肾脏疾病的主要病因。现就RhoA/ROCK信号通路在肾间质纤维化和糖尿病肾病发病机制中的作用作一综述。

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