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华西医学  2014 

伊马替尼为基础治疗骨破坏为首发表现的费城染色体阳性急性淋巴细胞白血病一例并文献复习

DOI: 10.7507/1002-0179.20140187, PP. 620-623

Keywords: 伊马替尼,骨骼破坏,急性淋巴细胞白血病

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Abstract:

目的 报道并分析1例以骨破坏为首发表现的费城染色体阳性(Ph+)急性淋巴细胞白血病(ALL),采用伊马替尼为基础个体化方案的诊断和治疗。方法 采用病例报告及文献复习的方式对以骨破坏起病的ALL患者及Ph+ALL治疗进展进行描述。结果 患者诊断Ph+ALL明确,经伊马替尼为基础治疗获得诱导缓解,维持分子学缓解17个月。结论 对以骨破坏为首发表现者,应考虑ALL诊断可能;伊马替尼为基础的标准化疗方案有可能改善Ph+ALL的治疗模式和预后。

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