全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
华西医学  2014 

溴隐亭治疗垂体泌乳素瘤对患者心脏瓣膜影响的研究

DOI: 10.7507/1002-0179.20140141, PP. 467-469

Keywords: 溴隐亭,垂体泌乳素瘤,心脏瓣膜疾病

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的 研究长期使用溴隐亭治疗垂体泌乳素腺瘤是否会增加心脏瓣膜反流的危险。方法 于2012年1月-2013年2月间随访纳入26例使用溴隐亭治疗垂体泌乳素腺瘤至少6个月的患者(观察组),并与101例健康人对照(对照组),两组均行经胸心脏彩色多普勒超声检查,记录二维超声值及各瓣膜反流情况,比较两组上述心脏彩色多普勒超声数据。结果 观察组三尖瓣微量反流比例(38.46%)较对照组(19.80%)高,差异有统计学意义(P=0.046),余瓣膜反流与对照组差异无统计学意义;观察组室间隔厚度(8.62±0.31)mm较对照组(8.57±0.12)mm高,差异有统计学意义(P=0.042)。结论 使用溴隐亭治疗垂体泌乳素腺瘤未观察到引起有临床意义的心脏瓣膜反流,但长期的心脏彩色多普勒超声随访是必要的。

References

[1]  [ 1 ] Colao A, Savastano S. Medical treatment of prolactinomas[J]. Nat Rev Endocrinol, 2011, 7(5): 267-278.
[2]  [ 2 ] Steiger M, Jost W, Grandas F, et al. Risk of valvular heart disease associated with the use of dopamine agonists in Parkinson’s disease: a systematic review[J]. J Neural Transm, 2009, 116(2): 179-191.
[3]  [ 3 ] Rasmussen VG, stergaard K, Dupont E, et al. The risk of valvular regurgitation in patients with Parkinson’s disease treated with dopamine receptor agonists[J]. Mov Disord, 2011, 26(5): 801-806.
[4]  [ 4 ] Elenkova A, Shabani R, Kalinov K, et al. Increased prevalence of subclinical cardiac valve fibrosis in patients with prolactinomas on long-term bromocriptine and cabergoline treatment[J]. Eur J Endocrinol, 2012, 167(1): 17-25.
[5]  [ 5 ] Boguszewski CL, dos Santos CM, Sakamoto KS, et al. A comparison of cabergoline and bromocriptine on the risk of valvular heart disease inc patients with prolactinomas[J]. Pituitary, 2012, 15(1): 44-49.
[6]  [ 6 ] Bogazzi F, Manetti L, Raffaelli V, et al. Cabergoline therapy and the risk of cardiac valve regurgitation in patients with hyperprolactinemia: a meta-analysis from clinical studies[J]. J Endocrinol Invest, 2008, 31(12): 1119-1123.
[7]  [ 7 ] Herring N, Szmigielski C, Becher H, et al. Valvular heart disease and the use of cabergoline for the treatment of prolactinoma[J]. Clin Endocrinol (Oxf), 2009, 70(1): 104-108.
[8]  [ 8 ] Kars M, Delgado V, Holman ER, et al. Aortic valve calcification and mild tricuspid regurgitation but no clinical heart disease after 8 years of dopamine agonist therapy for prolactinoma[J]. J Clin Endocrinol Metab, 2008, 93(9): 3348-3356.
[9]  [ 9 ] Colao A, Galderisi M, Di Sarno A, et al. Increased prevalence of tricuspid regurgitation in patients with prolactinomas chronically treated with cabergoline[J]. J Clin Endocrinol Metab, 2008, 93(10): 3777-3784.
[10]   Tan T, Cabrita IZ, Hensman D, et al. Assessment of cardiac valve dysfunction in patients receiving cabergoline treatment for hyperprolactinaemia[J]. Clin Endocrinol (Oxf), 2010, 73(3): 369-374.
[11]   Bogazzi F, Buralli S, Manetti L, et al. Treatment with low doses of cabergoline is not associated with increased prevalence of cardiac valve regurgitation in patients with hyperprolactinaemia[J]. Int J Clin Pract, 2008, 62(12): 1864-1869.
[12]   Halperin I, Aller J, Varela C, et al. No clinically significant valvular regurgitation in long-term cabergoline treatment for prolactinoma[J]. Clin Endocrinol (Oxf), 2012, 77(2): 275-280.
[13]   Vallette S, Serri K, Rivera J, et al. Long-term cabergoline therapy is not associated with valvular heart disease in patients with prolactinomas[J]. Pituitary, 2009, 12(3): 153-157.
[14]   Delgado V, Biermasz NR, van Thiel SW, et al. Changes in heart valve structure and function in patients treated with dopamine agonists for prolactinomas, a 2-year follow-up study[J]. Clin Endocrinol (Oxf), 2012, 77(1): 99-105.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133