聚明胶肽与羟乙基淀粉在创伤失血性休克中的应用比较

【】目的观察聚明胶肽注射液和羟乙基淀粉（130/0.4）氯化钠注射液对创伤失血性休克患者的临床治疗效果。方法将2006年6月-2008年10月创伤失血性休克患者32例随机分为聚明胶肽组和羟乙基淀粉组，每组16例。抢救时除采用止血、扩容、纠酸等综合措施外，分别输入聚明胶肽注射液和羟乙基淀粉（130/0.4）氯化钠注射液1500mL。两组均监测血压、尿量和血气分析指标，比较两组指标恢复正常以及所需的时间。结果聚明胶肽组与羟乙基淀粉组上述指标恢复正常及所需的时间无差异，两组生存率、致残率及并发症均无差异。结论聚明胶肽注射液用于创伤失血性休克的疗效与羟乙基淀粉（130/0.4）氯化钠注射液相当。【Abstract】ObjectiveToobservetheclinicaleffectsofpolygelineinjectionandhydroxyethylstarch(130/0.4)NaClinjection(HES)onthetraumatichemorrhagicshock.MethodsAtotalof32patientswithtraumatichemorrhagicshockwererandomlydividedintopolygelineinjectiongroupandHESgroup,with16patientsineach.Thesamemeasuressuchashemstasis,expandingbloodvolume,correctionofacidbasedisturbanceandsoonwereadoptedinthebothgroups.ThepatientsinthepolygelineinjectiongroupandHESgroupwererespectivelytreatedwithpolygelineinjectionandHESNaClinjectioninadoseof1500mLbyintravenousinfusion.ThetimefrominjectiontotherecoveryofBP,urinaryoutput,andbloodgastonormallevelwasrecorded.ResultsBP,urinaryoutput,andbloodgaswereallimprovedsignificantly,therewasnosignificantdifferencebetweenthetwogroups(P>0.05).ConclusionTheclinicaleffectofpolygelineinjectiononstabilizingBPandimprovingmicrocirculationappearscomparabletothatofHES.