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华西医学  2010 

轻度认知功能障碍心理学特点和危险因素分析

, PP. 1391-1393

Keywords: 轻度认知功能障碍,神经心理学,危险因素

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Abstract:

【】目的探讨轻度认知功能障碍的心理学特点及其危险因素。方法由神经专科医生采集2009年9-12月在神经内科门诊就诊患者106例的临床资料,进行简易智能量表(MMSE)、听觉词语测验(AVLT)、画钟测验(CDT)、日常生活功能量表(ADL)、Hamilton抑郁量表(HDRS)及临床痴呆评定量表(CDR)等神经心理测试。根据检查结果分为MCI组与对照组。结果MCI组受教育年限低于对照组(P<0.05),高血压病、糖尿病、脑卒中史高于对照组(P<0.05)。Logistic多因素回归分析显示受教育年限和高血压病史与MCI密切相关。MCI组MMSE总分、CDT得分、AVLT即刻记忆、延迟记忆及长时延迟再认显著低于对照组,ADL评分及HDRS评分高于对照组(P<0.05)。结论高血压病是MCI的危险因素,较高的受教育年限是MCI的保护因素。MCI患者在多个神经心理学领域受损。【Abstract】ObjectiveToinvestigatetheneuropsychologicalcharacteristicsofmildcognitiveimpairment(MCI)anditsriskfactors.MethodsTheclinicaldataof106patientsinourneurologicdepartmentfromseptembertoDecember2009,werecollectedbyneurologists,andtestedthembyChineseversionofthemini-mentalstateexamination(MMSE),auditoryverballearningtest(AVLT),clockdrawingtest(CDT)、activitiesofdailyliving(ADL)、Hamiltondepressionratingscale(HDRS)andclinicaldementiaratingscale(CDR).AllsubjectsweredividedintoMCIpatientsgroupandthecontrolgroup.ResultsEducationallevelwassignificantlylowerandhypertension,diabetesmellitusandstrokehistoryweresignificantlymoreinpatientswithMCIthanthecontrol.ThefactorsassociatedwithMCIinlogisticregressionanalysiswerelowereducationallevelandhypertension.ThescoresofMMSE、CDTandAVLTofMCIweresignificantlylowerthanthoseofthecontrol,andthescoresofADLandHDRSweresignificantlyhigherthanthoseofthecontrol(P<0.05).ConclusionHypertensionistheriskfactorandhigheducationallevelistheprotectivefactorforMCI.MCIpatientsareimpairedinmultipleneuropsychologicaldomains.

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