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华西医学  2011 

异基因造血干细胞移植术后毛细血管渗漏综合征临床特征及危险因素分析

, PP. 1774-1779

Keywords: 异基因造血干细胞移植,毛细血管渗漏综合征,羟乙基淀粉

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Abstract:

【】 目的 分析异基因造血干细胞移植术(allogeneichematopoieticstemcelltransplantation,allo-HSCT)后并发毛细血管渗漏综合征(capillaryleaksyndrome,CLS)的发生率、危险因素和结局,并探讨其防治措施。 方法 回顾性分析2005年6月-2011年2月住院的allo-HSCT术后14例并发CLS的临床资料。 结果 CLS发生率为9.2%(14/152)。年龄、性别、诊断、HLA配型、预处理、CD34+细胞量、粒细胞集落刺激因子(granulocytecolony-stimulatingfactor,G-CSF)用量、植入时间均不能认定为造血干细胞移植后CLS诱发因素。 结论 HSCT术后CLS诱因尚不清楚,采用限水、减量G-CSF、使用糖皮质激素和羟乙基淀粉等措施及时治疗,有助于控制CLS。【Abstract】 Objective Tostudytheoccurrencerate,riskfactorsandoutcomesofcapillaryleaksyndrome(CLS)afterallogeneichematopoieticstemcelltransplantation(allo-HSCT),anddiscussitspreventionandtreatment. Methods Weretrospectivelyanalyzedtheclinicalrecordsof14allo-HSCTrecipientscomplicatedwithCLSfromJune2005toFebruary2011. Results Fourteenoutof152patientsdevelopedCLSwithacumulativeincidenceof9.2%.Noneofthe8clinicalparametersincludingage,gender,underlyingdisease,donortype,conditioningregimen,CD34+celldose,granulocytecolony-stimulatingfactor(G-CSF)dosage,anddaystoneutrophilengraftmentcouldbeidentifiedasriskfactorsfortheoccurrenceofCLS. Conclusions RiskfactorsforCLSafterallo-HSCThavenotbeenfullyestablished.Restrictionofwaterintake,administrationofcorticosteroidsandhydroxyethylstarchcanbebeneficialforpatientswithCLS.

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