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华西医学  2011 

骨髓增殖性肿瘤发病机制的研究进展及临床应用

, PP. 1798-1804

Keywords: 骨髓增殖性肿瘤,发病机制,诊断标准及流程

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Abstract:

【】 近年来大量的研究对骨髓增殖性疾病发病机制有了更进一步的认识。其中最重要的发现是出现在绝大多数阵型红细胞增多症和一半左右原发性血小板增多症及骨髓纤维化的JAK2V617F突变,能使细胞增殖活性明显增强,并引起细胞的增殖和凋亡抑制。其他的突变包括JAK2外显子12突变、MPL突变等。对慢性粒细胞白血病的急变机制及对伊马替尼的耐药机制也有了更多的认识。这些新的发现影响了慢性骨髓增殖性肿瘤的诊断标准与流程,并对其治疗提供了新的靶点。

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