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华西医学  2011 

人工肝支持系统治疗造血干细胞移植后并发重症肝静脉闭塞病

, PP. 1787-1790

Keywords: 人工肝,造血干细胞移植,肝静脉闭塞病

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Abstract:

【】 目的 了解人工肝支持系统抢救造血干细胞移植合并重症肝静脉闭塞病的临床疗效。 方法 对2002年1月-2010年12月因造血干细胞移植并发重症肝静脉闭塞病的6例患者,利用人工肝支持系统,选用血浆置换程序进行血浆置换。 结果 6例患者经血浆置换治疗后,胆红素均明显下降,3例最终恢复,2例因肝功能再次恶化死亡,1例死于严重混合性感染。 结论 人工肝支持系统抢救造血干细胞移植合并重症肝静脉闭塞病是一种新的尝试,是有效和可靠的。【Abstract】 Objective Toexplorethetherapeuticefficacyofartificialliversupportsystemonseverehepaticveno-occlusivediseaseaccompaniedwithhematopoieticstemcelltransplantation. Methods BetweenJanuary2002andDecember2010,sixpatientswithseverehepaticveno-occlusivediseaseaccompaniedwithhematopoieticstemcelltransplantationunderwentplasmaexchangewithplasmaexchangeproceduresusingartificialliversupportsystem. Results Afterplasmaexchangetreatment,thebilirubinsofsixpatientssignificantlydecreased;threepatientseventuallyrecovered,twodiedbecauseofliverfunctiondeterioratedagain,andonediedofseveremixedinfections. Conclusion Artificialliversupportsystemiseffectiveandreliableforhematopoieticstemcelltransplantationaccompaniedwithseverehepaticveno-occlusivedisease.

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