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华西医学  2011 

静脉滴注胺碘酮致肝肾功能不全一例及文献分析

, PP. 1611-1614

Keywords: 胺碘酮,肝功能不全,肾功能不全

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Abstract:

【】 目的 报道1例静脉滴注胺碘酮致肝肾功能不全患者。 方法 2010年10月收治1例扩张性心肌病患者,治疗过程中使用胺碘酮注射液,导致严重的肝肾功能不全。系统查阅中国期刊全文数据库及外文数据库Pubmed、Embase建库至2011年8月关于胺碘酮致肝肾功能不全的相关文献,进行静脉胺碘酮致肝肾功能不全的可能性评估,探索胺碘酮静脉滴注致肝功能不全的的作用机制。 结果 根据查阅文献结果分析,此患者静脉注射胺碘酮致肝功不全的可能性高,Naranjo概率评分分别为7分。 结论 提出临床医师和临床药师应进行胺碘酮静脉的药学监护,高度的重视胺碘酮相关的不良反应,从而及时识别和防治胺碘酮所致肝肾功能不全,减少其不良预后。【Abstract】 Objective Toreportacaseofhepaticandrenalinsufficiencyinducedbyintravenousinjectionwithamiodarone,andtoevaluatethepossibilityoftheadversedrugreaction. Methods ApatientwithdilatedcardiomyopathywasadmittedinOctober,2010.Duringtheprocedure,theuseofamiodaronehydrochlorideinjectionmadethepatientsufferfromliverandkidneydysfunction.WeretrievedtheliteraturesaboutliverandkidneytoxicityofamiodaronefromCNKI,Pubmed,andEmbase(fromtheestablishmentofthedatabasestoNovember2011).Wealsossessedthepossibilityoftheadversedrugreaction,discussedthemechanismofamiodarone-inducedhepaticinsufficiency. Results Accordingtotheliterature,Therewasagreatpossibilityofhepaticinsufficiencyinducedbyamiodarone,andthetotalscoreoftheNaranjoprobabilityscorewas7. Conclusion Itisimportanttopaymoreattentiontothepharmaceuticalcareofamidaronetotimelyrecognizeandeffectivelypreventortreathepaticandrenalinsufficiencyinducedbyintravenousinjectionwithamiodarone.

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