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华西医学  2015 

肾球旁细胞瘤的临床病理观察

DOI: 10.7507/1002-0179.20150598, PP. 2115-2117

Keywords: 肾球旁细胞瘤,电子显微镜,免疫组织化学

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Abstract:

目的?探讨肾球旁细胞瘤的临床病理特征、诊断与鉴别诊断。方法?对于2012年11月21日就诊的1例肾球旁细胞瘤的临床表现、病理改变和超微结构改变进行观察分析并作文献复习。结果?患者临床表现为高血压、高肾素血症、高醛固酮血症和低血钾。左肾实质内见一巨大肿瘤,行左肾切除术。光学显微镜下见形态一致的多边形或圆形肿瘤细胞呈片状、巢团状或围血管生长,可见血管外皮瘤样构像;免疫组织化学呈CD34弥漫阳性,平滑肌肌动蛋白局灶阳性,广谱细胞角蛋白、上皮细胞膜抗原、S-100、人黑色素瘤特异性抗体、嗜铬素A、突触素均阴性;透射电子显微镜下可见特征性菱形晶体(前肾素颗粒),确诊为肾球旁细胞瘤。结论?肾球旁细胞瘤是少见的肾脏肿瘤,易误诊为其他肿瘤,知晓该病并熟悉其组织病理学和超微结构特征是正确诊断的关键。

References

[1]  1 Robertson PW, Klidjian A, Harding LK, et al. Hypertension due to a renin-secreting renal tumour[J]. Am J Med, 1967, 43(6): 963-976.
[2]  2 Prejbisz A, Antoniewicz AA, Kabat M, et al. Reninsecreting juxtaglomerular cell tumor of the kidney causing severe hypertension and polyuria[J]. Pol Arch Med Wewn, 2014, 124(4): 207-208.
[3]  3 John NE, Guido S, Jonathan E, et al. World Health Organization Classification of tumours: pathology & genetics of tumours of the urinary system and male genital organs[M]. Elsevier, 2004.
[4]  4 Dong D, Li H, Yan W, et al. Juxtaglomerular cell tumor of the kidney: -a new classification scheme[J]. Urol Oncol, 2010, 28(1): 34-38.
[5]  5 Endoh Y, Motoyama T, Hayami S, et al. Juxtaglomerular cell tumor of the kidney: report of a non-functioning variant[J]. Pathol Int, 1997, 47(6): 393-396.
[6]  6 Squires JP, Ulbright TM, DeSchryver-Kecskemeti K, et al. Juxtaglomerular cell tumor of the kidney[J]. Cancer, 1984, 53(3): 516-523.
[7]  7 Kuroda N, Maris S, Monzon FA, et al. Juxtaglomerular cell tumor: a morphological, immunohistochemical and genetic study of six cases[J]. Hum Pathol, 2013, 44(1): 47-54.
[8]  8 Duan X, Bruneval P, Hammadeh R, et al. Metastatic juxtaglomerular cell tumor in a 52-year-old man[J]. Am J Surg Pathol, 2004, 28(8): 1098-1102.
[9]  9 Têtu B, Vaillancourt L, Camilleri JP, et al. Juxtaglomerular cell tumor of the kidney: report of two cases with a papillary pattern[J]. Hum Pathol, 1993, 24(11): 1168-1174.
[10]  10 Lachvac L, Svajdler M, Valansky L, et al. Juxtaglomerular cell tumor, causing fetal demise[J]. Int Urol Nephrol, 2011, 43(2): 365-370.
[11]  11 Martin SA, Mynderse LA, Lager DJ, et al. Juxtaglomerular cell tumor: a clinicopathologic study of four cases and review of the literature[J]. Am J Clin Pathol, 2001, 116(6): 854-863.
[12]  12 游燕, 梁智勇, 朱?, 等. 肾球旁细胞瘤2例临床病理探讨[J]. 诊断病理学杂志, 2012, 19(4): 259-262.
[13]  13 Kim HJ, Kim CH, Choi YJ, et al. Juxtaglomerular cell tumor of kidney with CD34 and CD117 immunoreactivity: report of 5 cases[J]. Arch Pathol Lab Med, 2006, 130(5): 707-711.
[14]  14 Shao L, Manalang M, Cooley L. Juxtaglomerular cell tumor in an 8-year-old girl[J]. Pediatr Blood Cancer, 2008, 50(2): 406-409.
[15]  15 Capovilla M, Couturier J, Molinié V, et al. Loss of chromosomes 9 and 11 May be recurrent chromosome imbalances in juxtaglomerular cell tumors[J]. Hum Pathol, 2008, 39(3): 459-462.
[16]  16 Brandal P, Busund LT, Heim S. Chromosome abnormalities in juxtaglomerular cell tumors[J]. Cancer, 2005, 104(3): 504-510.
[17]  17 Steffens J, Bock R, Braedel HU, et al. Renin-producing renal cell carcinoma[J]. Eur Urol, 1990, 18(1): 56-60.
[18]  18 Lindop GB, Fleming S. Renin in renal cell carcinoma--an immunocytochemical study using an antibody to pure human renin[J]. J Clin Pathol, 1984, 37(1): 27-31.
[19]  19 Hasegawa T, Matsuno Y, Shimoda T, et al. Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior[J]. Hum Pathol, 1999, 30(12): 1464-1473.
[20]  20 Kuroda N. Editorial comment from Dr Kuroda to Glomus tumor of the kidney[J]. Int J Urol, 2011, 18(12): 871.
[21]  21 Gherardi GJ, Arya S, Hickler RB. Juxtaglomerular body tumor: a rare occult but curable cause of lethal hypertension[J]. Hum Pathol, 1974, 5(2): 236-240.
[22]  22 Kodet R, Taylor M, Váchalová H, et al. Juxtaglomerular cell tumor. An immunohistochemical, electron-microscopic, and in situ hybridization study[J]. Am J Surg Pathol, 1994, 18(8): 837-842.
[23]  23 Beaudoin J, Périgny M, Têtu B, et al. A patient with a juxtaglomerular cell tumor with histological vascular invasion[J]. Nat Clin Pract Nephrol, 2008, 4(8): 458-462.
[24]  24 Shera AH, Baba AA, Bakshi IH, et al. Recurrent malignant juxtaglomerular cell tumor: a rare cause of malignant hypertension in a child[J]. J Indian Assoc Pediatr Surg, 2011, 16(4): 152-154.

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