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华西医学  2015 

不同文化程度糖耐量正常人群血糖及胰岛功能的研究

DOI: 10.7507/1002-0179.20150573, PP. 2005-2008

Keywords: 文化程度,糖耐量正常,血糖,胰岛功能

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Abstract:

目的?研究不同文化程度的糖耐量正常人群血糖、胰岛功能情况,探讨文化程度与血糖及胰岛素抵抗的相关性。方法?电话联系2007年1月-2011年1月体检空腹血糖正常人群,进一步行口服葡萄糖耐量试验及胰岛功能检测,完成相关检查且糖耐量正常者340人,据文化程度分为高文化程度组(n=92)、中等文化程度组(n=194)、低文化程度组(n=54),询问相关病史,测量血糖、血脂、胰岛素等指标,计算胰岛素敏感指数(HOMA-S)、胰岛素抵抗指数(HOMA-IR)、β细胞分泌指数(HOMA-β),并比较3组间的差异。结果?随着文化程度的下降,空腹血糖、体质量指数(BMI)、空腹胰岛素、餐后胰岛素、HOMA-β、HOMA-IR逐渐升高,而HOMA-S逐渐下降。其中高文化程度组BMI、空腹胰岛素水平、HOMA-IR低于低文化程度组,中等文化程度组BMI、HOMA-IR显著低于低文化程度组,差异均有统计学意义(P<0.05)。以空腹血糖为因变量行回归分析显示空腹血糖与文化程度、年龄、BMI相关(P<0.05)。结论?随着文化程度的下降,BMI升高,HOMA-S下降,HOMA-IR升高,提示在糖耐量正常不同文化程度人群中,已经出现糖代谢及胰岛功能的差异,预示在低文化程度人群中未来发展为糖尿病的比例升高。

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