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华西医学  2012 

多发性骨髓瘤患者血清胱抑素C水平测定

DOI: CNKI:51-1356/R.20120214.1338.002, PP. 171-173

Keywords: 多发性骨髓瘤,血清胱抑素C,肾功能损害,肿瘤负荷,溶骨性损害

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Abstract:

目的 测定多发性骨髓瘤(MM)患者血清胱抑素C(Cys-C)的水平,探讨Cys-C与国际分期体系(ISS)、血β2-微球蛋白、溶骨性损害等指标的关系。方法 收集2008年1月-2010年9月32例初治和8例复发的MM患者作为研究对象,同时收集40例健康体检者的检查资料作为对照组,测定血清Cys-C、血肌酐(Scr)、血β2-微球蛋白。采用核素全身骨显像(ECT)观察患者的溶骨性病变部位数。结果 患者血清Cys-C水平(1.40mg/L)明显高于健康对照组(0.90mg/L)(P<0.01);在MM患者中Cys-C比Scr更敏感,能反映肾小球滤过率;血清Cys-C水平与ISS分期晚,血β2-微球蛋白升高以及溶骨性病变进展密切相关。结论 MM患者的Cys-C水平高于健康者。Cys-C是骨髓瘤肾损害的早期敏感标志物,与肿瘤负荷及溶骨性损害密切相关,可作为评价肿瘤负荷的潜在指标。ObjectiveToevaluatetheserumlevelsofcystatin-Cinpatientswithmultiplemyeloma(MM),andtoexploreitspossiblecorrelationswithclinicaldata,includingISSstage,serumβ2-microglobulin,andadvancedlyticlesions.Methods FromJanuary2008toSeptember2010,serumcystatin-C,creatinine(Scr),andβ2-microglobulinin32patientswithMM,8patientswithrelapseddisease,andin40healthycontrolsweredetectedbyautomaticbiochemistryanalyzerdetection.AccordingtoskeletonECT,gradingofosteolyticlesionwasobserved.Results Thelevelsofserumcystatin-CofpatientswithMMweresignificantlyhigherthanthoseofthecontrols.Serumcystatin-Ccouldreflecttheglomerularfiltrationrate,andwasmoresensitivethanScrinpatientswithrenallesion.Serumcystatin-ChadstrongercorrelationswithadvancedISSstages,highlevelsofserumβ2-microglobulin,andextensivebonediseases.Conclusion Serumcystatin-CisasensitivemarkerofrenallesioninpatientswithMM,itcouldbeapotentialindicatortoassessthetumorburden.

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