全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
华西医学  2013 

多靶点酪氨酸激酶抑制剂的临床应用进展

DOI: 10.7507/1002-0179.20130349, PP. 1123-1126

Keywords: 蛋白酪氨酸激酶抑制剂,多靶点,靶向治疗,抗肿瘤药

Full-Text   Cite this paper   Add to My Lib

Abstract:

蛋白酪氨酸激酶介导的信号传导通路是目前研究较多且效果明显的抗肿瘤药物靶点,多靶点酪氨酸激酶抑制剂能够抑制多个信号传导通路,诱导肿瘤细胞的凋亡,阻断新生血管的生成,抑制肿瘤细胞的增殖,是近几年上市的主要抗肿瘤药物。现对多靶点酪氨酸激酶抑制剂的临床应用、注意事项及目前研究进展进行综述。

References

[1]  [ 1 ] Scagliotti G, Novello S, von Pawel J, et al. PhaseⅢ study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer[J]. J Clin Oncol, 2010, 28(11): 1835-1842.
[2]  [ 2 ] Mcdermott DF, Sosman JA, Gonzalez R, et al. Double-blind randomized phaseⅡ study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group[J]. J Clin Oncol, 2008, 26(13): 2178-2185.
[3]  [ 3 ] Raymond E, Dahan L, Raoul JL, et al. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors[J]. N Engl J Med, 2011, 364(6): 501-513.
[4]  [ 4 ] Bergh J, Bondarenko IM, Lichinitser MR, et al. First-line treatment of advanced breast cancer with sunitinib in combination with docetaxel versus docetaxel alone: results of a prospective, randomized phaseⅢ study[J]. J Clin Oncol, 2012, 30(9): 921-929.
[5]  [ 5 ] Robert NJ, Saleh MN, Paul D, et al. Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phaseⅢ, randomized, open-label trial[J]. Clin Breast Cancer, 2011, 11(2): 82-92.
[6]  [ 6 ] Barrios CH, Liu MC, Lee SC, et al. PhaseⅢ randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer[J]. Breast Cancer Res Treat, 2010, 121(1): 121-131.
[7]  [ 7 ] Grávalos C, Grande E, Gasent JM. The potential role of sunitinib in gastrointestinal cancers other than GIST[J]. Crit Rev Oncol Hematol, 2010, 76(1): 36-43.
[8]  [ 8 ] Govidan V, Krzakowski M, Szczesna A, et al. Sunitinib plus erlotinib versus placebo plus erlotinib in patients with previously treated advanced non-small-cell lung cancer: a phaseⅢ trial[J]. J Clin Oncol, 2012, 30(17): 2070-2078.
[9]  [ 9 ] Copland M, Hamilton A, Elrick LJ, et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction[J]. Blood, 2006, 107(11): 4532-4539.
[10]   Park SI, Zhang J, Phillips KA, et al. Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model[J]. Cancer Res, 2008, 68(9): 3323-3333.
[11]   Montemurro M, Sch?ffski P, Reichardt P, et al. Nilotinib in the treatment of advanced gastrointestinal stromal tumours resistant to both imatinib and sunitinib[J]. Eur J Cancer, 2009, 45(13): 2293-2297.
[12]   陶玲, 卓文磊, 杨帆, 等. 凡德他尼治疗非小细胞肺癌的meta分析[J]. 中国肺癌杂志, 2012, 5( 03): 172-178.
[13]   Lin NU, Diéras V, Paul D, et al. Multicenter phaseⅡ study of lapatinib in patients with brain metastases from HER2-positive breast cancer[J]. Clin Cancer Res, 2009, 15(4): 1452-1459.
[14]   Kim HP, Han SW, Kim SH, et al. Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells[J]. Mol Cancer Ther, 2008, 7(3): 607-615.
[15]   van der Graaf WT, Blay JY, Chawla SP, et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial[J]. Lancet, 2012, 379(9829): 1879-1886.
[16]   Rugo HS, Herbst RS, Liu G, et al. PhaseⅠ trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results[J]. J Clin Oncol, 2005, 23(24): 5474-5483.
[17]   Rini BI, Escudier B, Tomczak P, et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial[J]. Lancet, 2011, 378(9807): 1931-1939.
[18]   Quintás-Cardama A, Vaddi K, Liu P, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms[J]. Blood, 2010, 115(15): 3109-3117.
[19]   Verstovsek S, Mesa RA, Gotlib J, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis[J]. N Engl J Med, 2012, 366(9): 799-807.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133