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华西医学  2013 

分化抑制因子-1在肝细胞肝癌中的表达及与预后相关性的初步研究

DOI: 10.7507/1002-0179.20130273, PP. 871-874

Keywords: 分化抑制因子1,肝癌,预后

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Abstract:

目的 检测分化抑制因子1(Id-1)在肝细胞肝癌组织中和正常肝组织中的表达情况,了解Id-1与肝细胞肝癌患者预后关系。方法 对获得的19例肝细胞肝癌组织标本和8例正常肝组织进行免疫组织化学染色,并对染色结果进行分级。借助SPSS软件,分析肝细胞肝癌组织标本与正常肝组织标本中的Id-1表达强度区别,Id-1与甲胎蛋白(AFP)相关性,及Id-1表达强度与肝癌患者预后之间的关系。结果 免疫组织化学染色结果显示所有标本均表达为阳性,其中3例(+),7例(++),10例(+++)7例(++++),肝细胞肝癌组织标本与正常肝组织标本差异有统计学意义(P<0.05);Id-1表达与血液中AFP水平相关不显著(r=?0.121,P=0.621);Spearman等级相关分析显示患者生存时间与Id-1表达呈负相关(r=?0.567,P=0.011)。结论 Id-1在肝癌组织中表达增高,Id-1表达水平与生存时间呈负相关,但和AFP无明显相关。

References

[1]  [ 1 ] Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012[J]. CA Cancer J Clin, 2012, 62(1): 10-29.
[2]   宋光, 刘晶, 张男. 甲胎蛋白(AFP)与原发性肝癌早期诊断的关系[J]. 人人健康?医学导刊, 2008(5): 54-56.
[3]   Forootan SS, Wong YC, Dodson A, et al. Increased Id-1 expression is significantly associated with poor survival of patients with prostate Cancer[J]. Hum Pathol, 2007, 38(9): 1321-1329.
[4]   Perk J, Iavarone A, Benezra R, et al. Id family of helix-loop-helix proteins in Cancer[J]. Nat Rev Cancer, 2005, 5(8): 603-614.
[5]  [ 2 ] Parkin DM, Bray FI, Devesa SS. Cancer burden in the year 2000. The global picture[J]. Eur J Cancer, 2001, 37(Supp18): 4-66.
[6]  [ 3 ] Block TM, Mehta AS, Fimmel CJ, et al. Molecular viral oncology of hepatocellular carcinoma[J]. Oncogene, 2003, 22(33): 5093-5107.
[7]  [ 4 ] Ruzinova MB, Benezra R. Id proteins in development, cell cycleand Cancer[J]. Trends Cell Biol, 2003, 13(8): 410-418.
[8]  [ 5 ] Norton JD. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis[J]. J Cell Sci, 2000, 113(22): 3897-3905.
[9]  [ 6 ] Ding R, Han S, Lu Y, et al. Overexpressed Id-1 is associated with patient prognosis and HBx expression in hepatitis B virus-related hepatocellular carcinoma[J]. Cancer Biol Ther, 2010, 10(3): 299-307.
[10]  [ 7 ] Le Jossic C, Ilyin GP, Loyer P, et al. Expression of helix-loop-helix factor Id-1 is dependent on the hepatocyte proliferation and differentiation status in rat liver and in primary culture[J]. Cancer Res, 1994, 54(23): 6065-6068.
[11]  [ 8 ] Ohtani N, Zebedee Z, Huot TJ, et al. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence[J]. Nature, 2001, 409(6823): 1067-1070.
[12]  [ 9 ] Lee TK, Man K, Ling MT, et al. Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway[J]. Carcinogenesis, 2003, 24(11): 1729-1736.
[13]   Alani RM, Young AZ, Shifflett CB. Id-1 regulation of cellular senescence through transcriptional repression of p16/Ink4a[J]. Proc Natl Acad Sci U S A, 2001, 98(14): 7812-7816.
[14]   李晓军, 秦浚川. 分化抑制因子的研究进展[J]. 生物化学与生物物理学进展, 2004, 31(10): 865-869.
[15]   Ao J, Meng J, Zhu L, et al. Activation of androgen receptor induces Id-1 and promotes hepatocellular carcinoma cell migration and invasion[J]. Mol Oncol, 2012, 6(5): 507-515.
[16]   Fong S, Debs RJ, Desprez PY. Id genes and proteins as promising targets in Cancer therapy[J]. Trends Mol Med, 2004, 10(8): 387-392.

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