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华西医学  2013 

白细胞介素-33在自身免疫性疾病发病机制中的作用研究进展

DOI: 10.7507/1002-0179.20130295, PP. 937-939

Keywords: 白细胞介素33,自身免疫性疾病,研究进展

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Abstract:

自身免疫性疾病(AID)是由自身免疫应答引起的慢性炎症性疾病,该类疾病大多数原因不明,可能与遗传、感染及环境等因素有关。白细胞介素-33(IL-33)作为一种炎性细胞因子,通过IL-33/ST2信号通路调节免疫应答,从而参与疾病的发生和发展。AID的病程一般较长并反复迁延,临床治疗困难。研究IL-33与AID之间的关系,为AID致病机理的研究、疾病的诊断和治疗提供新的方向。

References

[1]   黄鹤卿, 穆荣, 刘霞, 等.白细胞介素-33的测定及其与早期类风湿关节炎相关性的研究[J]. 中华风湿病学杂志, 2010, 14(7): 446-448.
[2]   施巍宇, 杨再兴. 血清IL-33与系统性红斑狼疮的关系研究[J]. 现代检验医学杂志, 2010, 25(5): 5-7.
[3]   Mok MY, Huang FP, Lp WK, et al. Serum levels of IL-33 and soluble ST2 and their association with disease activity in systemic lupus erythematosus[J]. Rheumatology (Oxford), 2010, 49(3): 520-527.
[4]   Manetti M, Ibba-Manneschi L, Liakouli V, et al. The IL1-like cytokine IL 33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis[J]. Ann Rheum Dis, 2010, 69(3): 598-605.
[5]   Yanaba K, Yoshizaki A, Asano Y, et al. Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis[J]. Clin Rheumatol, 2011, 30(6): 825-830.
[6]   Manetti M, Guiducci S, Ceccarelli C, et al. Increased circulating levels of interleukin 33 in systemic sclerosis correlate with early disease stage and microvascular involvement[J]. Ann Rheum Dis, 2011, 70(10): 1876-1878.
[7]   Rankin AL, Mumm JB, Murphy E, et al. IL-33 induces IL-13-dependent cutaneous fibrosis[J]. J Immunol, 2010, 184(3): 1526-1535.
[8]   Iwakura Y, Ishigame H. The IL-23/IL-17 axis in inflammation[J]. J Clin Invest, 2006, 116(5): 1218-1222.
[9]   IHan GW, Zeng LW, Liang CX, et al. Serum levels of IL-33 is increased in patients with ankylosing spondylitis[J]. Clin Rheumatol, 2011, 30(12): 1583-1588.
[10]   ITalabot-Ayer D, McKee T, Gindre P, et al. Distinct serum and synovial fluid interleukin (IL)-33 levels in rheumatoid arthritis, psoriatic arthritis and osteoarthritis[J]. Joint Bone Spine, 2012, 79(1): 32-37.
[11]  [ 1 ] Schmitz J, Owyang A, Oldham E, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-l receptor-related protein ST2 and induces T helper type 2-associated cytokines[J]. Immunity, 2005, 23(5): 479-490.
[12]  [ 2 ] Tominaga S. A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1receptor[J]. FEBS Lett, 1989, 258(2): 301-304.
[13]  [ 3 ] Chackerian AA, Oldham ER, Murphy EE, et al. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex[J].Immunol, 2007, 179 (4): 2551-2555.
[14]  [ 4 ] Dinarello CA. An IL-l family member requires caspase-1 processing and signals through the ST2 receptor[J].Immunity, 2005, 23(5): 46l-462.
[15]  [ 5 ] Ali S, Huber M, Kollewe C, Bischoff SC, et al. IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells[J]. Proc Natl Acad Sci USA, 2007, 104(47): 18660-18665.
[16]  [ 8 ] Komai-Koma M, Gilchrist DS, McKenzie AN, et al. IL-33 activates B1 cells and exacerbates contact sensitivity[J]. J Immunol, 2011, 186(4): 2584-2591.
[17]  [ 9 ] Kurowska-Stolarska M, Kewin P, Murphy G, et al. IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4[J]. J Immunol, 2008, 181(7): 4780-4790.
[18]   Xu D, Jiang HR, Kewin P, et a1. IL-33 exacerbates antigen-induced arthritis by activating mast cells[J]. Proc Natl Acad Sci USA, 2008, 105(31): l0913-109l8.
[19]   陈立辉, 张源潮, 孟红艳.检测早期类风湿关节炎(RA)患者血清中IL-33水平的临床意义[J].中国医药指南, 2012, 15(10): 424-425.
[20]   刘?,周迎春,黄钟.类风湿性关节炎患者IL-33水平变化与疾病严重程度的关系[J].医学检验与临床, 2012, 23(3): 54-56.
[21]  [ 6 ] Rank MA, Kobayashi T, Kozaki H, et al. IL-33-activated dendritic cells induce an atypical TH2-type response[J]. J Allergy Clin Immunol, 2009, 123(5): 1047-1054.
[22]  [ 7 ] Miller AM, Xu D, Asquith DL, et al. IL-33 reduces the development of atherosclerosis[J]. J Exp Med, 2008, 205(2): 339-346.

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