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华西医学  2013 

乙型肝炎病毒X蛋白的研究进展

DOI: 10.7507/1002-0179.20130194, PP. 609-613

Keywords: X蛋白,乙型肝炎病毒,复制,肝细胞癌

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Abstract:

乙型肝炎病毒(HBV)慢性持续感染与肝细胞癌(HCC)的发生密切相关。由HBVX基因编码的X蛋白(HBx)是一个多功能蛋白,可通过反式激活和蛋白相互作用持续调控病毒的生活周期和宿主细胞的代谢,最终导致肝细胞癌变。因此,近年来对于HBx在病毒复制和致HCC中的作用机制成为研究热点。

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