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华西医学  2013 

髓母细胞瘤中相关信号通路与靶向抑制剂研究进展

DOI: 10.7507/1002-0179.20130197, PP. 623-626

Keywords: 髓母细胞瘤,信号传导,靶向抑制剂,综述

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Abstract:

髓母细胞瘤(MD)是一种高发于儿童的恶性脑肿瘤。虽然目前还没有针对这一肿瘤的理想治疗措施,但近来的研究表明在该肿瘤的发病机制中一些相关的信号通路扮演着十分重要的角色。深入研究这些信号传导通路及其相互作用关系有助于对MD发病机制的进一步认识。在这些信号通路中,SHH(sonichedgehogsignalingpathway)对髓母细胞瘤的形成最具有特异性。因此针对SHH信号通路的靶向抑制剂的研究得到了深入地开展,并展现出良好的应用前景。现就MD发病机制中的信号通路和基于SHH信号通路靶向抑制剂的研究进展作一综述,为探索更加有效的治疗方法提供新的理论依据。

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