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华西医学  2013 

非小细胞肺癌放射治疗过程中肿瘤体积变化的动态观察及临床分析

DOI: 10.7507/1002-0179.20130055, PP. 167-171

Keywords: 非小细胞肺癌,锥形束CT,肿瘤体积

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Abstract:

目的 通过非小细胞肺癌(NSCLC)图像引导放射治疗(IGRT)过程中,每次治疗前获取的锥形束CT图像,动态观察肿瘤体积的变化。方法 2009年2月-2010年8月18例周围型NSCLC患者接受IGRT。每次治疗前进行千伏级锥形束CT(KV-CBCT)图像的采集。每周在KV-CBCT图像上勾画肿瘤靶区并计算靶区体积,经统计后分析肿瘤治疗过程中体积的变化。结果 治疗开始时平均体积为28.5cm3(2.5~109.1cm3),治疗结束时平均体积为17.1cm3(1.4~73.4cm3)。平均退缩率为35.9%(3.9%~68.9%),平均每天的退缩率为1.5%(0.1%~5.4%)。治疗结束时,0例病灶完全消退,1例部分消退,10例微小消退,7例稳定。结论 治疗过程中,NSCLC肿瘤的退缩可以通过KV-CBCT进行观察。当病灶为周围型时,能对肿瘤体积的变化进行客观有效的评价。放射治疗过程中肿瘤的体积改变具有很大的异质性,肿瘤在治疗过程中体积均有一定的退缩,但治疗结束时大多数病灶仅为微小消退或稳定。

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