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华西医学  2013 

18氟?脱氧葡萄糖双探头符合线路显像诊断非小细胞肺癌胸内淋巴结转移

DOI: 10.7507/1002?0179.20130053, PP. 161-165

Keywords: 非小细胞肺癌,18氟-脱氧葡萄糖,双探头符合线路,淋巴结

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Abstract:

目的 探讨18氟-脱氧葡萄糖(18F-FDG)双探头符合线路对非小细胞肺癌胸内淋巴结转移的诊断价值,并分析其假阳性、假阴性诊断的原因。方法 回顾性分析2010年12月-2012年6月非小细胞肺癌患者161例的临床资料,其中腺癌122例,鳞癌23例,其他类型16例。分析患者术前18F-FDG双探头符合线路显像对肺门、纵膈淋巴结的诊断结果(其中阳性53例,阴性108例),以术后病理诊断为金标准,评价其诊断价值。分析9例假阳性、26例假阴性诊断患者的吸烟史、慢性支气管炎肺气肿、肺结核病史、局限性肺炎、肿瘤标志物、淋巴结短径、肿瘤原发灶T/N比值、外周血白细胞等指标。结果 18F-FDG双探头符合线路单光子发射计算机断层成像(SPECT)诊断非小细胞肺癌淋巴结转移的灵敏度、特异性、准确性、阳性预测值、阴性预测值分别是62.9%、90.1%、78.3%、83%、75.9%。假阳性组患者慢支炎肺气肿、局限性肺炎者高于真阳性组。假阴性组的淋巴结短径、原发灶T/N比值小于真阳性组。结论 18F-FDG双探头符合线路SPECT是术前诊断肺癌淋巴结转移的有效手段;假阳性淋巴结与慢支炎肺气肿、局限性肺炎有关;假阴性淋巴结与淋巴结短短径小、原发肿瘤摄取18F-FDG低有关。

References

[1]  [ 1 ] Darling GE, Dickie AJ, Malthaner RA, et al. Invasive mediastinal staging of non-small-cell lung cancer: a clinical practice guideline[J]. Curr Oncol, 2011, 18(6): 304-310.
[2]  [ 2 ] Dwamena BA, Sonnad SS, Angobaldo JO, et al. Metastases from non-small cell lung cancer: mediastinal staging in the 1990s-meta-analytic comparison of PET and CT[J]. Radiology, 1999, 213(2): 530-536.
[3]  [ 3 ] Alongi F, Ragusa P, Montemaggi P, et al. Combining independent studies of diagnostic fluorodeoxyglucose positron-emission tomography and computed tomography in mediastinal lymph node staging for non-small cell lung cancer[J]. Tumori, 2006, 92(4): 327-333.
[4]  [ 4 ] Eschmann SM, Bitzer M, Paulsen F, et al. The benefit of functional-anatomical imaging with [18F]fluorodeoxyglucose utilizing a dual-head coincidence gamma camera with an integrated X-ray transmission system in non-small cell lung cancer[J]. Nucl Med Commun, 2004, 25(9): 909-915.
[5]  [ 5 ] Stevens H, Bakker PF, Schlosser NJ, et al. Use of a dual-head coincidence camera and 18F-FDG for detection and nodal staging of non-small cell lung cancer: accuracy as determined by 2 independent observers[J]. J Nucl Med, 2003, 44(3): 336-340.
[6]  [ 6 ] Ose N, Sawabata N, Minami M, et al. Lymph node metastasis diagnosis using positron emission tomography with 2-[F- fluoro-2-deoxy-D-glucose as a tracer and computed tomography in surgical cases of non-small cell lung cancer[J]. Eur J Cardio-Thorac , 2012, 42(1): 89-92.
[7]  [ 7 ] Zhang H, Tian M, Oriuchi N, et al. Detection of lung cancer with positron coincidence gamma camera using fluorodeoxyglucose in comparison with dedicated PET[J]. Eur J Radiol , 2003, 47(3): 199-205.
[8]  [ 8 ] Konishi J, Yamazaki K, Tsukamoto E, et al. Mediastinal lymph node staging by FDG-PET in patients with non-small cell lung cancer: analysis of false-positive FDG-PET findings[J]. Respiration, 2003, 70(5): 500-506.
[9]  [ 9 ] Wrona A, Jassem J. The new TNM classification in lung cancer[J]. Pneumonol Alergol Pol, 2010, 78(6): 407-417.
[10]   Weber WA, Neverve J, Sklarek J , et al. Imaging of lung cancer with fluorine-18 fluorodeoxyglucose: comparison of a dual-head gamma camera in coincidence mode with a full-ring positron emission tomography system[J]. Eur J Nucl Med, 1999, 26(4): 388-395.
[11]   Oturai PS, Mortensen J, Enevoldsen H, et al. Gamma-camera 18F-FDG PET in diagnosis and staging of patients presenting with suspected lung cancer and comparison with dedicated PET[J]. J Nucl Med, 2004, 45(8): 1351-1357.
[12]   Stevens H, Bakker PF, Schlosser NJ, et al. Use of a dual-head coincidence camera and 18F-FDG for detection and nodal staging of non-small cell lung cancer: accuracy as determined by 2 independent observers[J]. J Nucl Med, 2003, 44(3): 336-340.
[13]   Roman MR, Rossleigh MA, Angelides S, et al. Staging and managing lung tumors using F-18 FDG coincidence detection[J]. Clin Nucl Med, 2001, 26(5): 383-388.
[14]   Zimny M, Hochstenbag M, Lamers R, et al. Mediastinal staging of lung cancer with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography and a dual-head coincidence gamma camera[J]. Eur Radiol, 2003, 13(4): 740-747.
[15]   Lee SM, Park CM, Paeng JC, et al. Accuracy and predictive features of FDG-PET/CT and CT for diagnosis of lymph node metastasis of T1 non-small-cell lung cancer manifesting as a subsolid nodule[J]. Eur Radiol, 2012, 22(7): 1556-1563.
[16]   Tsubamoto M, Kuriyama K, Kido S, et al. Detection of lung cancer on chest radiographs: analysis on the basis of size and extent of ground-glass opacity at thin-section CT[J]. Radiology, 2002, 224(1): 139-144.
[17]   Nomori H, Watanabe K, Ohtsuka T, et al. The size of metastatic foci and lymph nodes yielding false-negative and false-positive lymph node staging with positron emission tomography in patients with lung cancer[J]. J Thorac Cardiovasc Surg, 2004, 127(4): 1087-1092.

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