[ 1 ] Richards MJ, Edwards JR, Culver DH, et al. Nosocomial infections in medical intensive care units in the United States[J]. Crit Care Med, 1999, 27(5): 887-892.
[2]
[ 2 ] Chastre J, Jy F. Ventilator-associated pneumonia[J]. Am J Respir Crit Care Med, 2002, 165(7): 867-903.
[3]
[ 3 ] Safdar N, Dezfulian C, Collard HR, et al. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review[J]. Crit Care Med, 2005, 33(10): 2184-2193.
[4]
[ 4 ] van der Waaij D, Berghuis-de Vries JM, Lekkerkerk-van der Wees JEC. Colonization resistance of the digestive tract in conventional and antibiotic-treated mice[J]. J Hyg (Lond), 1971, 69(3): 405-411.
[5]
[ 5 ] Stoutenbeek CP, van Saene HK, Miranda DR, et al. The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients[J]. Intensive Care Med, 1984, 10(4): 185-192.
[6]
[ 6 ] De La Cal MA, Cerdá E, García-Hierro P, et al. Survival benefit in critically ill burned patients receiving selective decontamination of the digestive tract: a randomized, placebo-controlled, double-blind trial[J]. Ann Surg, 2005, 241(3): 424-430.
[7]
[ 7 ] Liberati A, D’amico R, Torri V, et al. Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care[J]. Cochrane Database Syst Rev, 2004(1): CD000022.
[8]
[ 8 ] Vandenbroucke-Grauls CM, Vandenbroucke JP. Effect of selective decontamination of the digestive tract on respiratory tract infections and mortality in the intensive care unit[J]. Lancet, 1991, 338(8771): 859-862.
[9]
[ 9 ] Kollef MH. Opinion: the clinical use of selective digestive decontamination[J]. Crit Care, 2000, 4(6): 327-332.
[10]
Gastinne H, Wolff M, Delatour F, et al. A controlled trial in intensive care units of selective decontamination of the digestive tract with nonabsorbable antibiotics. The French Study Group on Selective Decontamination of the Digestive Tract[J]. N Engl J Med, 1992, 326(9): 594-599.
[11]
Bastin AJ, Ryanna KB. Use of selective decontamination of the digestive tract in United Kingdom intensive care units[J]. Anaesthesia, 2009, 64(1): 46-49.
[12]
Paster BJ, Boches SK, Galvin JL, et al. Bacterial diversity in human subgingival plaque[J]. J Bacteriol, 2001, 183(12): 3770-3783.
[13]
Garrouste-Orgeas M, Chevret S, Arlet G, et al. Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit patients. A prospective study based on genomic DNA analysis[J]. Am J Respir Crit Care Med, 1997, 156(5): 1647-1655.
[14]
Garcia R. A review of the possible role of oral and dental colonization on the occurrence of health care-associated pneumonia: underappreciated risk and a call for interventions[J]. Am J Infect Control, 2005, 33(9): 527-541.
[15]
DeRiso AJⅡ, Ladowski JS, Dillon TA, et al. Chlorhexidine gluconate 0.12% oral rinse reduces the incidence of total nosocomial respiratory infection and nonprophylactic systemic antibiotic use in patients undergoing heart surgery[J]. Chest, 1996, 109(6): 1556-1561.
[16]
Fourrier F, Cau-Pottier E, Boutigny H, et al. Effects of dental plaque antiseptic decontamination on bacterial colonization and nosocomial infections in critically ill patients[J]. Intensive Care Med, 2000, 26(9): 1239-1247.
[17]
Bergmans DC, Bonten MJ, Gaillard CA, et al. Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled study[J]. Am J Respir Crit Care Med, 2001, 164(3): 382-388.
[18]
Fourrier F, Dubois D, Pronnier P, et al. Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit: a double-blind placebo-controlled multicenter study[J]. Crit Care Med, 2005, 33(8): 1728-1735.
[19]
Seguin P, Tanguy M, Laviolle B, et al. Effect of oropharyngeal decontamination by povidone-iodine on ventilator-associated pneumonia in patients with head trauma[J]. Crit Care Med, 2006, 34(5): 1514-1519.
[20]
Koeman M, Van Der Ven AJ, Hak E, et al. Oral decontamination with chlorhexidine reduces the incidence of ventilator-associated pneumonia[J]. Am J Respir Crit Care Med, 2006, 173(12): 1348-1355.
[21]
Segers P, Speekenbrink RG, Ubbink DT, et al. Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial[J]. JAMA, 2006, 296(20): 2460-2466.
[22]
Tantipong H, Morkchareonpong C, Jaiyindee S, et al. Randomized controlled trial and meta-analysis of oral decontamination with 2% chlorhexidine solution for the prevention of ventilator-associated pneumonia[J]. Infect Control Hosp Epidemiol, 2008, 29(2): 131-136.
[23]
Bellissimo-Rodrigues F, Bellissimo-Rodrigues WT, Viana JM, et al. Effectiveness of oral rinse with chlorhexidine in preventing nosocomial respiratory tract infections among intensive care unit patients[J]. Infect Control Hosp Epidemiol, 2009, 30(10): 952-958.
[24]
Scannapieco FA, Yu J, Raghavendran K, et al. A randomized trial of chlorhexidine gluconate on oral bacterial pathogens in mechanically ventilated patients[J]. Crit Care, 2009, 13(4): R117.
