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华西医学  2014 

尿酸和白细胞与急性冠状动脉综合征严重程度的相关性研究

DOI: 10.7507/1002-0179.20140552, PP. 1814-1817

Keywords: 白细胞,尿酸,冠状动脉粥样硬化性心脏病,急性冠状动脉综合征,相关性

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Abstract:

目的 评估尿酸、白细胞与急性冠状动脉综合征严重程度的相关性。方法 回顾性分析2010年1月-12月23例急性心肌梗死(AMI)患者(AMI组)、17例不稳定型心绞痛(UA)患者(UA组)和17例健康体检者(对照组)在入院后24h内收集的白细胞及其分类、血小板参数、尿酸、血脂值,进行统计分析。结果 AMI组、UA组和对照组白细胞计数分别为(10.4±3.2)、(6.9±2.4)、(5.4±1.1)×109/L,差异有统计学意义(P<0.001);中性粒细胞计数分别为(7.4±3.2)、(4.8±2.3)、(3.4±0.8)×109/L,差异有统计学意义(P<0.001);尿酸水平分别为(401.4±94.3)、(384.1±74.1)、(285.5±76.8)μmol/L,差异有统计学意义(P<0.001)。多分类logistic回归分析示,以UA组为参照,白细胞计数与AMI相关(OR=1.712,P=0.003),尿酸水平与AMI无关(OR=1.006,P=0.255);以对照组为参照,白细胞计数与AMI相关(OR=2.942,P=0.004)、与UA无关(OR=1.718,P=0.125),尿酸与AMI、UA相关(OR=1.027,P=0.016;OR=1.021,P=0.041)。结论 尿酸可能与冠心病的慢性进展有关,白细胞则可能与冠状动脉斑块不稳定、AMI发生有关。

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