Ishimura H, Takahashi T, Nakagawa H, et al. N-acetylglucosaminyltransferase Ⅴ and beta1-6 branching N-linked oligosaccharides are associated with good prognosis of patients with bladder cancer[J]. Clin Cancer Res, 2006, 12(8): 2506-2511.
[2]
Dosaka-Akita H, Miyoshi E, Suzuki O, et al. Expression of N-acetylglucosaminyltransferase Ⅴ is associated with prognosis and histology in non-small cell lung cancers[J]. Clin Cancer Res, 2004, 10(5): 1773-1779.
[3]
Takahashi T, Hagisawa S, Yoshikawa K, et al. Predictive value of N-acetylglucosaminyltransferase-Ⅴ for superficial bladder cancer recurrence[J]. J Urol, 2006, 175(1): 90-93.
[4]
Pinho SS, Figueiredo J, Cabral J, et al. E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferasesⅢ andⅤ[J]. Biochim Biophys Acta, 2013, 1830(3): 2690-2700.
Gheldof A, Berx G. Cadherins and epithelial-to-mesenchymal transition[J]. Prog Mol Biol Transl Sci, 2013, 116: 317-336.
[7]
Partridge EA, Le Roy C, Di Guglielmo GM, et al. Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis[J]. Science, 2004, 306(5693): 120-124.
[8]
Kimura A, Terao M, Kato A, et al. Upregulation of N-acetylglucosaminyltransferase-V by heparin-binding EGF-like growth factor induces keratinocyte proliferation and epidermal hyperplasia[J]. Exp Dermatol, 2012, 21(7): 515-519.
[9]
Miyoshi E, Ihara Y, Nishikawa A, et al. Gene expression of N-acetylglucosaminyltransferasesⅢ andⅤ: a possible implication for liver regeneration[J]. Hepatology, 1995, 22(6): 1847-1855.
[10]
Uma？a P, Jean-Mairet J, Bailey JE. Tetracycline-regulated overexpression of glycosyltransferases in Chinese hamster ovary cells[J]. Biotechnol Bioeng, 1999, 65(5): 542-549.
[11]
Taniguchi N, Korekane H. Branched N-glycans and their implications for cell adhesion, signaling and clinical applications for cancer biomarkers and in therapeutics[J]. BMB Rep, 2011, 44(12): 772-781.
[12]
Nakahara S, Saito T, Kondo N, et al. A secreted type of beta1,6 N-acetylglucosaminyltransferaseⅤ(GnT-Ⅴ), a novel angiogenesis inducer, is regulated by gamma-secretase[J]. FASEB J, 2006, 20(14): 2451-2459.
[13]
Gu J, Nishikawa A, Tsuruoka N, et al. Purification and characterization of UDP-N-acetylglucosamine: alpha-6-D-mannoside beta 1-6N-acetylglucosaminyltransferase (N-acetylglucosaminyltransferase Ⅴ) from a human lung cancer cell line[J]. J Biochem, 1993, 113(5): 614-619.
[14]
Saito T, Miyoshi E, Sasai K, et al. A secreted type of beta 1,6-N-acetylglucosaminyltransferaseⅤ(GnT-Ⅴ) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-Ⅴdistinct from the original glycosyltransferase activity[J]. J Biol Chem, 2002, 277(19): 17002-17008.
[15]
Barillari G, Albonici L, Franzese O, et al. The basic residues of placenta growth factor type 2 retrieve sequestered angiogenic factors into a soluble form: implications for tumor angiogenesis[J]. Am J Pathol, 1998, 152(5): 1161-1166.
[16]
Murata K, Miyoshi E, Kameyama M, et al. Expression of N-acetylglucosaminyltransferaseⅤ in colorectal cancer correlates with metastasis and poor prognosis[J]. Clin Cancer Res, 2000, 6(5): 1772-1777.
[17]
Handerson T, Camp R, Harigopal M, et al. Beta1,6-branched oligosaccharides are increased in lymph node metastases and predict poor outcome in breast carcinoma[J]. Clin Cancer Res, 2005, 11(8): 2969-2973.
[18]
Yanagi M, Aoyagi Y, Suda T, et al. N-Acetylglucosaminyltransferase Ⅴ as a possible aid for the evaluation of tumor invasiveness in patients with hepatocellular carcinoma[J]. J Gastroenterol Hepatol, 2001, 16(11): 1282-1289.
[19]
Hart GW, Copeland RJ. Glycomics hits the big time[J]. Cell, 2010, 143(5): 672-676.
[20]
Dennis JW, Granovsky M, Warren CE. Protein glycosylation in development and disease[J]. Bioessays, 1999, 21(5): 412-421.
[21]
[ 1 ] Dennis JW, Laferté S, Waghorne C, et al. Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis[J]. Science, 1987, 236(481): 582-585.
[22]
[ 2 ] Granovsky M, Fata J, Pawling J, et al. Suppression of tumor growth and metastasis in Mgat5-deficient mice[J]. Nat Med, 2000, 6(3): 306-312.
[23]
[ 3 ] Saito H, Gu J, Nishikawa A, et al. Organization of the human N-acetylglucosaminyltransferase Ⅴgene[J]. Eur J Biochem, 1995, 233(1): 18-26.
[24]
[ 4 ] Ko JH, Miyoshi E, Noda K, et al. Regulation of the GnT-Ⅴpromoter by transcription factor Ets-1 in various cancer cell lines[J]. J Biol Chem, 1999, 274(33): 22941-22948.
[25]
[ 5 ] Buckhaults P, Chen L, Fregien N, et al. Transcriptional regulation of N-acetylglucosaminyltransferaseⅤ by the src oncogene[J]. J Biol Chem, 1997, 272(31): 19575-19581.
[26]
[ 6 ] Chen L, Zhang W, Fregien N, et al. The her-2/neu oncogene stimulates the transcription of N-acetylglucosaminyltransferase Ⅴ and expression of its cell surface oligosaccharide products[J]. Oncogene, 1998, 17(16): 2087-2093.
[27]
[ 7 ] Taniguchi N, Miyoshi E, Ko JH, et al. Implication of N-acetylglucosaminyltransferasesⅢ andⅤ in cancer: gene regulation and signaling mechanism[J]. Biochim Biophys Acta, 1999, 1455(2/3): 287-300.
[28]
[ 8 ] Lüthy R, Mclachlan AD, Eisenberg D. Secondary structure-based profiles: use of structure-conserving scoring tables in searching protein sequence databases for structural similarities[J]. Proteins, 1991, 10(3): 229-239.
[29]
[ 9 ] Ihara S, Miyoshi E, Nakahara S, et al. Addition of beta1-6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against trypsin[J]. Glycobiology, 2004, 14(2): 139-146.
[30]
Ihara S, Miyoshi E, Ko JH, et al. Prometastatic effect of N-acetylglucosaminyltransferaseⅤ is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching[J]. J Biol Chem, 2002, 277(19): 16960-16967.
[31]
Xu Q, Isaji T, Lu Y, et al. Roles of N-acetylglucosaminyltransferase Ⅲ in epithelial-to-mesenchymal transition induced by transforming growth factor β1 (TGF-β1) in epithelial cell lines[J]. J Biol Chem, 2012, 287(20): 16563-16574.
